Morris, Lynn, Martin, Desmond J., Bredell, Helba, Nyoka, Stephina N., Sacks, Leonard, Pendle, Stella, Page-Shipp, Liesl, Karp, Christopher L., Sterling, Timothy R., Quinn, Thomas C., and Chaisson, Richard E.
During 6 months of treatment, we measured human im-munodeficiency virus (HIV)-1 virus loads, CD4 T cell counts, and immune activation markers, in 111 HIV-1-infected patients with active tuberculosis (TB). The median virus load (baseline, 5.58 log[SUB10] copies/mL) significantly increased at 1 month (5.71 log[SUB10] copies/mL), then returned to near-baseline levels at 3 months (5.40 log[SUB10] copies/mL) and at 6 months (5.36 Log[SUB10] copies/mL). In contrast, the median CD4 counts increased at 1 month (186/mm[SUP3]), at 3 months (238/mm[SUP3]), and at 6 months (239/mm[SUP3]). CD4 counts and virus loads did not change during therapy. Expression of CD38 and HLA-DR remained high throughout treatment, whereas plasma levels of interleukin-6 decreased over time. [ABSTRACT FROM AUTHOR]