1. Longitudinal Analysis of Lymphocyte Ratios and HIV-1 Intracellular DNA Levels in Children.
- Author
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Saitoh, Akihiko, Powell, Christine A., Fenton, Terence, Douglas, Steven D., Starr, Stuart E., Fletcher, Courtney V., and Spector, Stephen A.
- Subjects
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HIV , *HIV infections , *DNA , *ANTIRETROVIRAL agents , *LYMPHOCYTES , *VIRAL replication , *NUCLEOSIDES - Abstract
The associations between human immunodeficiency virus type 1 (HIV-1) intracellular DNA and immunological markers were analyzed longitudinally for children with sustained, undetectable RNA levels while receiving highly active antiretroviral therapy (HAART) for >2 years. When DNA levels reached a plateau at week 104 of therapy, in contrast to findings for adults, there was no correlation between the CD4+:CD8+ ratio and DNA levels (r = -0.02; P = .95), and naive CD4+CD45RA+ lymphocytes predominated. These data suggest that the increased proportion of naive lymphocytes found in children are less susceptible to HIV-1 infection than are the memory lymphocytes that dominate immune reconstitution in adults. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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