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Start Over Author "Wozniak, David M." Journal journal of infectious diseases
3 results on '"Wozniak, David M."'

1. Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16 + Monocytes

Author

Lüdtke, Anja, primary, Ruibal, Paula, additional, Becker-Ziaja, Beate, additional, Rottstegge, Monika, additional, Wozniak, David M., additional, Cabeza-Cabrerizo, Mar, additional, Thorenz, Anja, additional, Weller, Romy, additional, Kerber, Romy, additional, Idoyaga, Juliana, additional, Magassouba, N'Faly, additional, Gabriel, Martin, additional, Günther, Stephan, additional, Oestereich, Lisa, additional, and Muñoz-Fontela, César, additional

Published
2016
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2. Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.

Author

Lüdtke, Anja, Ruibal, Paula, Becker-Ziaja, Beate, Rottstegge, Monika, Wozniak, David M., Cabeza-Cabrerizo, Mar, Thorenz, Anja, Weller, Romy, Kerber, Romy, Idoyaga, Juliana, Magassouba, N'Faly, Gabriel, Martin, Günther, Stephan, Oestereich, Lisa, and Muñoz-Fontela, César

Subjects
EBOLA virus disease, CD antigens, VIRUS inactivation, MONOCYTES, DENDRITIC cells, NEUTROPHILS, DIAGNOSIS
Abstract

A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16+ monocytes with a poor activation profile. In survivors, CD16+ monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology. [ABSTRACT FROM AUTHOR]

Published
2016
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3. Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.

Author

Lüdtke A, Ruibal P, Becker-Ziaja B, Rottstegge M, Wozniak DM, Cabeza-Cabrerizo M, Thorenz A, Weller R, Kerber R, Idoyaga J, Magassouba N, Gabriel M, Günther S, Oestereich L, and Muñoz-Fontela C

Subjects
Dendritic Cells virology, Ebolavirus isolation & purification, Female, Hemorrhagic Fever, Ebola diagnosis, Hemorrhagic Fever, Ebola physiopathology, Hemorrhagic Fever, Ebola virology, Humans, Kinetics, Mobile Health Units, Monocytes virology, Neutrophils virology, Phenotype, Dendritic Cells immunology, Ebolavirus immunology, Hemorrhagic Fever, Ebola immunology, Monocytes immunology, Neutrophils immunology, Receptors, IgG immunology
Abstract

A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16 + monocytes with a poor activation profile. In survivors, CD16 + monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology., (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.)

Published
2016
Full Text
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