1. Type 2 Vaccine-Derived Poliovirus from Patients with Acute Flaccid Paralysis in China: Current Immunization Strategy Effectively Prevented Its Sustained Transmission.
- Author
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Yong Zhang, Dongmei Yan, Shuangli Zhu, Ning Wen, Li Li, Haiyan Wang, Jianfeng Liu, Xufang Ye, Zhengrong Ding, Dongyan Wang, Hui Zhu, Li Chen, Xiaohui Hou, Hongqiu An, Xiaofeng Liang, Huiming Luo, Kew, Olen, and Wenbo Xu
- Subjects
FLACCID dysarthria ,IMMUNIZATION ,PREVENTION of infectious disease transmission ,POLIOMYELITIS vaccines ,VIRUS-induced immunosuppression - Abstract
In China, 5 patients with acute flaccid paralysis (AFP) associated with type 2 vaccine-derived poliovirus (VDPV) were identified by an AFP surveillance system from 1996 through 2009. A maximum-likelihood tree shows that all 5 Chinese VDPVs were independent. These 5 VDPVs were 100-216 d old according to the number of synonymous substitutions per synonymous site and 176-292 d old according to the number of substitutions per site. This result indicates limited virus replication since the administration of the initiating oral polio vaccine (OPV) dose, which is consistent with the rapid evolution rate of poliovirus genomes. The abovementioned VDPVs have important implications in the global polio eradication initiative. Localized, limited, and transient circulation may be typical of OPVs; hence, independent VDPVs could be found because of the large population and excellent surveillance system, which permitted early detection and response, but sustained transmission was limited because of high population immunity. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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