Search

In this article, Fe3O4/GO and Fe3O4/ZnO/GO nanocomposites (NPs) synthesized by thermal treatment at 823 K, and their drug delivery properties for curcumin (CUR) as an anticancer drug were investigated. The structural, morphological, and magnetic properties of these Nps were studied. The results of XRD, FTIR and EDX analyses indicated the synthesis of pure and crystalline structures of GO, Fe3O4/GO and Fe3O4/ZnO/GO NPs. Moreover, the mean size of spherical shape in Fe3O4/GO and Fe3O4/ZnO/GO nanoparticles was 42.36 and 53.21 nm, respectively. Based on the results of release and loading at different pHs, the drug is well loaded on the NPs and released at the tumor site. Based on these studies, the drug loading percentage on Fe3O4/GO is higher than Fe3O4/ZnO/GO. Also, the results showed that 41.65% of the drug is released from Fe3O4/GO and 23.43% from Fe3O4/ZnO/GO in the first ten hours after being in the cancer cell site. The Hemolysis test of prepared NPs and the cytotoxicity of NCs and CUR-loaded on NCs against U87 cancer cells and fibroblast human cells were investigated using the MTT assay. The toxic effect of Fe3O4/GO and of Fe3O4/ZnO/GO was more in U87 cancer cells compared to normal fibroblast cells. The results of anticancer activity of Nano-carriers on brain cancer cell lines revealed that CUR-loaded nanocrystals (NCs) have significant cytotoxicity activity on U87. Therefore, these NCs are capable of acting as drug delivery systems for anti-cancer drugs like CUR. [ABSTRACT FROM AUTHOR]

In this project, Calcium ferrite/polyvinyl alcohol (CaFe2O4@PVA) nanocarriers were prepared by a thermal-treatment method at three different temperatures (773, 823 and 923 K). The nanocarriers were used as drug delivery systems (DDS) to deliver curcumin (CUR) and were utilized as a new structure for photo dynamic therapy (PDT). Drug loading and release study of CUR were performed and it was observed that nanocarriers showed a pH dependent drug release behavior. MTT assay, Hemolysis assay and lethal dose test were applied to determine the cytotoxicity of nanocarriers. These tests indicated that synthesized nanocarriers can be considered as nontoxic. Also, the photodynamic therapy experiments were performed by two groups: one group of cells were treated by different concentrations of nanocarriers without light and the other group were exposed to light. Then, the efficacy of PDT was determined by MTT and it was revealed that whenever nanocarriers were exposed to light the cytotoxicity was significantly high. Therefore, it was revealed that these nanocarriers are suitable to be utilized as a drug delivery systems and photo dynamic therapy agent. [ABSTRACT FROM AUTHOR]

In the present study the effect of nanodiamond (ND) on the adsorption capacity of Drug has been investigated. Thermal oxidation nanodiamond (OND) was used as adsorbents for Methotrexate adsorption. The surface properties of NDs were studied by Fourier transform infrared spectroscopy and zeta potential. It was determined that thermal oxidation changed the surface properties of ND, including increase the amount of carboxylic acid groups and decreasing the zeta potential of ND by increasing the thermal oxidation time. The adsorption experiments showed that untreated ND (UND) has large adsorption capacity and fast adsorption kinetic for methotrexate (MTX). These results suggest that the adsorption behavior of UND with the MTX follows not only the charge but also the chemical interaction. Due to form the strong hydrogen bond between the carboxyl groups of MTX and the oxygen containing groups on the surface of NDs, Kinetic studies showed that the kinetic data are well fitted with the pseudo- second-order model for most of the adsorbents. MTT assay, Hemolysis assay and acute toxicity were used for determining biocompatibility of the adsorbents; MTT assay showed no significant toxicity up to near 300 µg/mL, OND showed neglectable hemolysis and acute toxicity result demonstrated OND was nontoxic. [ABSTRACT FROM AUTHOR]

Abstract: In this work we reported the synthesis of tamoxifen (TMX) loaded l-tyrosine natural amino acids (Tyr) modified Fe3O4 magnetic nanoparticles. Tyr, which was containing phenol groups was selected to study their effects on biocompatibility, loading capacity and release profile of TMX. TMX loaded Tyr modified Fe3O4 magnetic nanoparticles (F@Tyr@TMX NPs) were characterized by X-ray diffraction, thermo gravimetric analysis, Fourier transform infrared spectroscopy, vibrating sample magnetometer, dynamic light scattering and transmission electron microscopy techniques. The results showed that the ζ-potential of F@Tyr@TMX NPs was about − 12.8 mV and the average size was 22.19 ± 3.58 [mean ± SD (n = 50)] nm. The loading capacity of 11.34 ± 0.09% and encapsulation efficiency of 51.21 ± 0.41%. Additionally, hemolysis test and MTT assays on HEK-293 were performed for determination of biocompatibility of F@Tyr@TMX NPs. Finally, the anticancer activity of F@Tyr@TMX NPs studied on MCF-7 breast cancer cell lines. The results indicate that these as prepared magnetic nanoparticles are suitable for delivery of TMX and even other hydrophobic drugs.Graphical Abstract: [ABSTRACT FROM AUTHOR]

A low cytotoxic metal-organic framework (MOF) UiO-66 (UiO stands for University of Oslo) and NH-UiO-66, that showed high cell viability of HFF-2 via 3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyl tetrazolium assay, was reported as an effective adsorbent (antidotal) agents. The structure of MOFs was confirmed by Fourier transform infrared, Field emission scanning electron microscopy (FESEM) and X-ray diffraction. Thermal behavior of MOFs was investigated using with thermogravimetric analyzer in nitrogen atmosphere to check the thermal stability. FESEM showed NH-UiO-66 displayed symmetrical crystals with triangular base pyramid morphology, with the particle size around 100 nm and uniform size distribution. The specific surface areas were calculated using the Brunauer-Emmett-Teller method and surface area and total pore volume of NH-UiO-66 were calculated to be 1258 m/g and 0.51 cm/g, respectively. Methotrexate salt (MTX) was selected as the model drug which was adsorbed into inner pores and channels of MOFs by diffusion manner. The interaction between MOFs and MTX and the effect of pH on interaction between them in aqueous solution was investigated. The final results showed that UiO-66 have high adsorbing capacity and great affinity to MTX. [ABSTRACT FROM AUTHOR]

There was an incorrect labeling of the samples during the VSM experiment by the operator, which caused us to present an incorrect Ms for F@Tyr@TMX NPs in Fig. 6 revised below. Since the presented result is related to iron oxide nanoparticles, replacement of the image does not influence the main conclusions of the paper. In order to present valid results, we repeated the VSM experiments. [ABSTRACT FROM AUTHOR]