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The traditional negative selection algorithm with a randomly generated hypersphere detector is unable to satisfy the development needs of continuous learning due to the inherent defects of the detector. This paper proposes a novel negative selection algorithm for hyper-rectangle detectors that overcomes the shortcomings of randomly generated hyper-sphere detectors and lays the foundation for a negative selection algorithm with continuous learning capability. It uses self-sample clusters of equal-sized hypercubes instead of self-samples for training. The hyper-rectangle detectors are generated by cutting the nonself-space along the boundary of the self-sample clusters. The state space is covered without overlapping each other by self-sample clusters and detectors. The anomaly detection performance of the proposed method was demonstrated using Iris data, vowel recognition data (Vowel), and Wisconsin Breast Cancer (BCW) data. The experimental results show that the proposed method outperforms other artificial immune algorithms and clustering algorithms under the same parameter conditions. [ABSTRACT FROM AUTHOR]