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Your search keyword '"Ezzedine, Khaled"' showing total 20 results
Start Over Author "Ezzedine, Khaled" Journal journal of investigative dermatology
20 results on '"Ezzedine, Khaled"'

1. Whole-Body Positron Emission Tomography with 18F-Fluorodeoxyglucose/Magnetic Resonance Imaging as a Screening Tool for the Detection of Malignant Transformation in Individuals with Neurofibromatosis Type 1

Author

Fertitta, Laura, Jannic, Arnaud, Zehou, Ouidad, Bergqvist, Christina, Ferkal, Salah, Moryousef, Sabine, Lerman, Lionel, Mulé, Sébastien, Luciani, Alain, Bapst, Blanche, Ezzedine, Khaled, Ortonne, Nicolas, Itti, Emmanuel, and Wolkenstein, Pierre

Published
2024
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13. Determinants of Vitamin D Status in Caucasian Adults: Influence of Sun Exposure, Dietary Intake, Sociodemographic, Lifestyle, Anthropometric, and Genetic Factors

Author

Touvier, Mathilde, Deschasaux, Mélanie, Montourcy, Marion, Sutton, Angela, Charnaux, Nathalie, Kesse-Guyot, Emmanuelle, Assmann, Karen E., Fezeu, Léopold, Latino-Martel, Paule, Druesne-Pecollo, Nathalie, Guinot, Christiane, Latreille, Julie, Malvy, Denis, Galan, Pilar, Hercberg, Serge, Le Clerc, Sigrid, Souberbielle, Jean-Claude, and Ezzedine, Khaled

Published
2015
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15. Genome-Wide Analysis Identifies a Quantitative Trait Locus in the MHC Class II Region Associated with Generalized Vitiligo Age of Onset

Author

Jin, Ying, Birlea, Stanca A., Fain, Pamela R., Gowan, Katherine, Riccardi, Sheri L., Holland, Paulene J., Bennett, Dorothy C., Herbstman, Deborah M., Wallace, Margaret R., McCormack, Wayne T., Kemp, E. Helen, Gawkrodger, David J., Weetman, Anthony P., Picardo, Mauro, Leone, Giovanni, Taïeb, Alain, Jouary, Thomas, Ezzedine, Khaled, van Geel, Nanny, Lambert, Jo, Overbeck, Andreas, and Spritz, Richard A.

Published
2011
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16. Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP

Author

Birlea, Stanca A., Jin, Ying, Bennett, Dorothy C., Herbstman, Deborah M., Wallace, Margaret R., McCormack, Wayne T., Helen Kemp, E., Gawkrodger, David J., Weetman, Anthony P., Picardo, Mauro, Leone, Giovanni, Taïeb, Alain, Jouary, Thomas, Ezzedine, Khaled, van Geel, Nanja, Lambert, Jo, Overbeck, Andreas, Fain, Pamela R., and Spritz, Richard A.

Published
2011
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19. Whole-body 18F-FDG-PET/MRI as a screening tool for the detection of malignant transformation in individuals with Neurofibromatosis type 1

Author

Fertitta, Laura, Jannic, Arnaud, Zehou, Ouidad, Bergqvist, Christina, Ferkal, Salah, Moryousef, Sabine, Lerman, Lionel, Mulé, Sébastien, Luciani, Alain, Bapst, Blanche, Ezzedine, Khaled, Ortonne, Nicolas, Itti, Emmanuel, and Wolkenstein, Pierre

Abstract

Malignant peripheral nerve sheath tumors (MPNST) are the leading cause of death in Neurofibromatosis type 1 (NF1). They can result from premalignant neurofibromas (NF) including NF with atypia and atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP). Some phenotypic characteristics have been described as associated with their development. The aim was to outline our use of whole-body 18F-FDG-PET/MRI in adults with NF1, especially in the screening of asymptomatic individuals with a higher risk of developing a MPNST, and to study its impact on NF classification (malignant vs premalignant) and MPNST staging over time. Individuals with NF1 who underwent a 18F-FDG-PET/MRI between 2017 to 2021 were included, analyzing separately the screened population. Maximum standard uptake value and diffusion-weighed imaging were assessed. Biopsy/surgery confirmed the diagnosis. In all, 345 18F-FDG-PET/MRI were performed in 241 patients including 149 asymptomatic (62%), but at risk. Eight MPNST in 8 screened individuals (5%), 6 NF with atypia in 4 (3%) and 29 ANNUBP in 23 (15%) were diagnosed. Over time, the proportion of grade 3 MPNST and the malignant/premalignant ratio in screened individuals significantly decreased (p=0.03 and p<0.001, respectively). This study emphasizes the diagnostic and screening performances of whole-body 18F-FDG-PET/MRI in adults with NF1.

Published
2024
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20. Genome-Wide Analysis Identifies a Quantitative Trait Locus in the MHC Class II Region Associated with Generalized Vitiligo Age of Onset.

Author

Ying Jin, Birlea, Stanca A., Fain, Pamela R., Gowan, Katherine, Riccardi, Sheri L., Holland, Paulene J., Bennett, Dorothy C., Herbstman, Deborah M., Wallace, Margaret R., McCormack, Wayne T., Kemp, E Helen, Gawkrodger, David J., Weetman, Anthony P., Picardo, Mauro, Leone, Giovanni, Taïeb, Alain, Jouary, Thomas, Ezzedine, Khaled, van Geel, Nanny, and Lambert, Jo

Subjects
*VITILIGO, *GENOMES, *MELANOCYTES, *MAJOR histocompatibility complex, *LOCUS (Genetics), *MUCOUS membranes, *DISEASE susceptibility
Abstract

Generalized vitiligo is a common autoimmune disease in which acquired patchy depigmentation of skin, hair, and mucous membranes results from loss of melanocytes from involved areas. Previous genetic analyses have focused on vitiligo susceptibility, and have identified a number of genes involved in disease risk. Age of onset of generalized vitiligo also involves a substantial genetic component, but has not previously been studied systematically. In this study, we report a genome-wide association study of vitiligo age of onset in 1,339 generalized vitiligo patients, with replication in an independent cohort of 677 cases. We identified a quantitative trait locus for vitiligo age of onset in the major histocompatibility complex (MHC) class II region, located near c6orf10-BTNL2 (rs7758128; P=8.14 × 10−11), a region that is also associated with generalized vitiligo susceptibility. In contrast, there was no association of vitiligo age of onset with any other MHC or non-MHC loci that are associated with vitiligo susceptibility. These findings highlight the differing roles played by genes involved in vitiligo susceptibility versus vitiligo age of onset, and illustrate that genome-wide analyses can be used to identify genes involved in quantitative aspects of disease natural history, as well as disease susceptibility per se. [ABSTRACT FROM AUTHOR]

Published
2011
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