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Your search keyword '"Maria K. Hordinsky"' showing total 27 results
Start Over Author "Maria K. Hordinsky" Journal journal of investigative dermatology
27 results on '"Maria K. Hordinsky"'

1. LB785 Efficacy and safety of baricitinib in adults with Alopecia Areata: Phase 3 results from a randomized controlled trial (BRAVE-AA1)

Author

Katrin Holzwarth, W. Wu, Amy M. DeLozier, Natasha Atanaskova Mesinkovska, Justin M. Ko, Guanglei Yu, Brett A. King, O-Ki Kwon, Jill Shwed McCollam, Yves Dutronc, and Maria K. Hordinsky

Subjects
medicine.medical_specialty, business.industry, Baricitinib, Cell Biology, Dermatology, Alopecia areata, medicine.disease, Biochemistry, law.invention, Randomized controlled trial, law, Medicine, business, Molecular Biology
Published
2021

3. 596 Application of an artificial intelligence (AI) photographic device to track platelet-rich plasma treatment outcomes in females with alopecia

Author

Gretchen Bellefeuille, Maria K. Hordinsky, S. Esposito, O. Raymond, Ronda S. Farah, and J.A. Shaik

Subjects
medicine.medical_specialty, Physical medicine and rehabilitation, business.industry, Platelet-rich plasma, Track (disk drive), Treatment outcome, Medicine, Cell Biology, Dermatology, business, Molecular Biology, Biochemistry
Published
2021

8. 484 FDA cleared devices produce inconsistent platelet-rich plasma product

Author

J. Asaila, N. Hussain, Maria K. Hordinsky, Ronda S. Farah, G. Gregorich, J.A. Shaik, M. Inyang, N. Sadick, and Rebecca Freese

Subjects
Chromatography, Chemistry, Platelet-rich plasma, Product (mathematics), Cell Biology, Dermatology, Molecular Biology, Biochemistry, Clearance
Published
2020

9. How Can We Promote Physician-Directed Research in Complex Medical Dermatology?

Author

Victoria P. Werth and Maria K. Hordinsky

Subjects
0301 basic medicine, Research design, medicine.medical_specialty, Biomedical Research, MEDLINE, Dermatology, Biochemistry, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Physician's Role, Molecular Biology, Extramural, business.industry, Internship and Residency, Cell Biology, United States, 030104 developmental biology, Education, Medical, Graduate, Research Design, Needs assessment, business, Needs Assessment
Published
2016

10. 393 Rare genetic mutations identify extracellular matrix genes as a contributing factor in alopecia areata etiology

Author

Iuliana Ionita-Laza, Sahar Gelfman, A.R. Abdelaziz, A. Lee, Christopher I. Amos, A. Floratos, Lynn Petukhova, David A. Norris, Maria K. Hordinsky, Madeleine Duvic, Vera H. Price, S. Erjavec, Wei Chen, P. Gregersen, and Angela M. Christiano

Subjects
Extracellular matrix, Immunology, Etiology, medicine, Cell Biology, Dermatology, Biology, Alopecia areata, medicine.disease, Molecular Biology, Biochemistry, Gene
Published
2019

12. 436 Scalp neuropathy in dermatomyositis patients with recalcitrant scalp pruritus

Author

A. Wipf, S. Foster, Ricardo Romiti, P.V. Cirino, Maria K. Hordinsky, William R. Kennedy, and Brian D. McAdams

Subjects
medicine.medical_specialty, business.industry, Cell Biology, Dermatology, Dermatomyositis, medicine.disease, Biochemistry, medicine.anatomical_structure, Scalp pruritus, Scalp, Medicine, business, Molecular Biology
Published
2018

13. 878 Individual variation in balance between platelet-secreted growth factors causing contradictory effects on hair follicle could potentially impact response to PRP therapy in patients with scalp hair loss

Author

Ronda S. Farah, Angela Wipf, Maria K. Hordinsky, Javed Mohammed, and M. Abedin

Subjects
medicine.medical_specialty, business.industry, Cell Biology, Dermatology, Hair follicle, Biochemistry, medicine.anatomical_structure, Endocrinology, Internal medicine, medicine, In patient, Platelet, business, Molecular Biology, Scalp hair loss, Balance (ability)
Published
2018

14. Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

Author

Joshua P. Slusser, Qingyi Wei, Madeleine Duvic, Vera H. Price, John D. Reveille, Angela Christiano, Maria K. Hordinsky, Nazila Barahmani, Mariza de Andrade, and David Norris

Subjects
Human leukocyte antigen class II, Alopecia Areata, Genes, MHC Class II, Dermatology, Biochemistry, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, HLA-DQ Antigens, medicine, HLA-DQ beta-Chains, Humans, Allele, Molecular Biology, Alleles, 030304 developmental biology, 0303 health sciences, business.industry, Histocompatibility Antigens Class I, HLA-DR Antigens, Cell Biology, Alopecia areata, medicine.disease, Immunology, business, HLA-DRB1 Chains
Published
2008

15. Phenotypic Analysis of T-Cells in Extensive Alopecia Areata Scalp Suggests Partial Tolerance

Author

Michelle L. Irvin, Marna E. Ericson, Maria K. Hordinsky, Lynne P. Steiner, Matthew J. Deeths, and Bart T. Endrizzi

Subjects
Adult, Antigens, Differentiation, T-Lymphocyte, CD4-Positive T-Lymphocytes, Male, Pathology, medicine.medical_specialty, Alopecia Areata, CD3 Complex, T-Lymphocytes, medicine.medical_treatment, CD4-CD8 Ratio, Dermatology, CD8-Positive T-Lymphocytes, Biochemistry, Interferon-gamma, Immunophenotyping, Antigen, Antigens, CD, medicine, Humans, Lectins, C-Type, Molecular Biology, Aged, integumentary system, biology, business.industry, Cell Biology, Middle Aged, Alopecia areata, medicine.disease, biology.organism_classification, Phenotype, Cytokine, Hair loss, medicine.anatomical_structure, Scalp, Interleukin-2, Immunohistochemistry, Female, business, Cabello
Abstract

This study demonstrates the feasibility and efficacy of using flow cytometric analysis with intracellular cytokine staining for characterization of T-cell phenotype and functional status in extensive alopecia areata (EAA) scalp skin. Cell suspensions were made from scalp punch biopsies taken from 12 patients with long-standing EAA (average disease duration 14 years, 95% hair loss) and six control subjects. EAA samples had a lower percentage of CD-3-expressing cells, but CD-4/CD-8 ratios remained similar to controls. Expression of CD-69 was found only in EAA scalp biopsies, suggesting that T-cells from EAA scalp have undergone activation. No difference was found in tumor necrosis factor alpha expression. Surprisingly, EAA scalp T-cells produced less IL-2 and CD-8 T-cells produced less IFN-gamma. Immunohistochemical staining of formalin-fixed paraffin-embedded specimens demonstrated that IFN-gamma-producing cells in EAA scalp were not greater in number than in normal specimens. The few identified IFN-gamma-producing cells demonstrated no tendency to localize to the perifollicular region, and were similarly distributed as in control specimens. The abnormalities in cytokine production may explain the relative paucity of inflammatory change observed in the clinical setting and suggest that T-cell responses in EAA scalp are tightly, albeit aberrantly, regulated via mechanisms of peripheral T-cell tolerance.

Published
2006

16. 308 Bone marrow/cord blood transplantation (BMCBT) ameliorates symptoms in some, but not all, subtypes of severe generalized junctional epidermolysis bullosa (JEB)

Author

Maria K. Hordinsky, John E. Wagner, Todd E. DeFor, Douglas R. Keene, Bruce R. Blazar, Katsuto Tamai, Rebecca Tryon, Christen L. Ebens, Jakub Tolar, M. Marinkovich, Kristen P. Hook, John A. McGrath, Mark J. Osborn, Alain Hovnanian, and Megan J. Riddle

Subjects
Pathology, medicine.medical_specialty, medicine.anatomical_structure, business.industry, Generalized junctional epidermolysis bullosa, Medicine, Cell Biology, Dermatology, Bone marrow, business, Molecular Biology, Biochemistry, Cord blood transplantation
Published
2017

17. 052 Identification of pathogenic T cell subsets in human alopecia areata

Author

A. de Jong, Julian Mackay-Wiggan, Luzhou Xing, Vera H. Price, Madeleine Duvic, Maria K. Hordinsky, Raphael Clynes, Ali Jabbari, David A. Lee, Angela M. Christiano, David A. Norris, and Z. Dai

Subjects
medicine.anatomical_structure, T cell, Immunology, medicine, Identification (biology), Cell Biology, Dermatology, Alopecia areata, Biology, medicine.disease, Molecular Biology, Biochemistry
Published
2017

19. 377 Type VII collagen (C7) expression and chimerism after bone marrow/cord blood transplantation (BMCBT) for severe generalized recessive dystrophic epidermolysis bullosa (RDEB)

Author

Rebecca Tryon, John A. Wagner, Maria K. Hordinsky, M.P. Marinkovich, Alain Hovnanian, John A. McGrath, David T. Woodley, Douglas R. Keene, Bruce R. Blazar, Kristen P. Hook, Katsuto Tamai, Christen L. Ebens, Mark J. Osborn, Jakub Tolar, Megan J. Riddle, Mei Chen, and Todd E. DeFor

Subjects
Pathology, medicine.medical_specialty, business.industry, Cell Biology, Dermatology, Biochemistry, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Type VII collagen, Recessive dystrophic epidermolysis bullosa, Medicine, Bone marrow, business, Molecular Biology, Cord blood transplantation
Published
2017

20. 287 Onabotulinum toxin injections for the treatment of psoriasis vulgaris: Efficacy and effects on neuropeptide expression

Author

William R. Kennedy, Maria K. Hordinsky, G. Wendelschafer Crabb, Ana Carina Junqueira Bertin, Marna E. Ericson, K. Aschenbeck, Ioanna G. Panoutsopoulou, Sima Kavand, and Dennis D. Dykstra

Subjects
Onabotulinum toxin, business.industry, Psoriasis, Neuropeptide, Medicine, Cell Biology, Dermatology, Pharmacology, business, medicine.disease, Molecular Biology, Biochemistry
Published
2016

21. 263 Skin engraftment and type VII collagen (C7) expression after allogeneic hematopoietic cell transplantation (HCT) for generalized severe recessive dystrophic epidermolysis bullosa (RDEB)

Author

Mark J. Osborn, Maria K. Hordinsky, Bruce R. Blazar, David T. Woodley, Douglas R. Keene, Katsuto Tamai, Kristen P. Hook, Jakub Tolar, P.M. Marinkovich, Mei Chen, John A. Wagner, John A. McGrath, and Alain Hovnanian

Subjects
Pathology, medicine.medical_specialty, Hematopoietic cell, business.industry, Cell Biology, Dermatology, Biochemistry, Transplantation, Type VII collagen, Immunology, Recessive dystrophic epidermolysis bullosa, medicine, business, Molecular Biology
Published
2016

22. 399 Expression quantitative trait loci (eQTL) mapping in a multicenter cross-sectional study of Alopecia Areata

Author

Madeleine Duvic, Lynn Petukhova, Ali Jabbari, Maria K. Hordinsky, David A. Norris, Jane E. Cerise, Julian Mackay-Wiggan, Vera H. Price, Raphael Clynes, and Angela M. Christiano

Subjects
Genetics, Cross-sectional study, Expression quantitative trait loci, medicine, Cell Biology, Dermatology, Biology, Alopecia areata, medicine.disease, Molecular Biology, Biochemistry
Published
2016

23. 689 Regional differences in scalp innervation: A pilot study of the healthy scalp

Author

S. Foster, K. Poss, William R. Kennedy, Gwen Wendelschafer-Crabb, Brian D. McAdams, Elisabeth Hurliman, and Maria K. Hordinsky

Subjects
medicine.anatomical_structure, business.industry, Scalp, Medicine, Cell Biology, Dermatology, Anatomy, business, Molecular Biology, Biochemistry, Regional differences
Published
2016

24. 292 Topical gabapentin for the treatment of symptomatic scalp in cicatricial alopecias

Author

Elisabeth Hurliman, David Miller, William R. Kennedy, Gwen Wendelschafer-Crabb, Erin M. Dodd, and Maria K. Hordinsky

Subjects
medicine.medical_specialty, medicine.anatomical_structure, Gabapentin, business.industry, Scalp, medicine, Cell Biology, Dermatology, business, Molecular Biology, Biochemistry, medicine.drug
Published
2016

25. 006 Correlation between frequency of circulating lesional T cell clones and disease severity in human Alopecia Areata

Author

Luzhou Xing, Z. Dai, David A. Lee, Maria K. Hordinsky, David A. Norris, Angela M. Christiano, A. de Jong, Vera H. Price, Raphael Clynes, Madeleine Duvic, Julian Mackay-Wiggan, and Ali Jabbari

Subjects
business.industry, T cell, Cell Biology, Dermatology, Alopecia areata, medicine.disease, Biochemistry, Correlation, medicine.anatomical_structure, Disease severity, Immunology, medicine, business, Molecular Biology
Published
2016

26. Neuropeptide Control Mechanisms in Cutaneous Biology: Physiological and Clinical Significance

Author

Marna E. Ericson, John C. Ansel, Kristina Seiffert, Thomas E. Scholzen, Maria K. Hordinsky, Eva M.J. Peters, Junichi Hosoi, and Ralf Paus

Subjects
Neurogenic inflammation, Lymphocyte, Vasoactive intestinal peptide, Neuropeptides, Inflammation, Dermatitis, Cell Biology, Dermatology, Biology, Neuropeptide Y receptor, Biochemistry, Proinflammatory cytokine, medicine.anatomical_structure, Immune system, Skin Physiological Phenomena, Immunology, medicine, Animals, Humans, Cytokine secretion, medicine.symptom, Molecular Biology, Skin
Abstract

The skin as a barrier and immune organ is exposed to omnipresent environmental challenges such as irradiation or chemical and biologic hazards. Neuropeptides released from cutaneous nerves or skin and immune cells in response to noxious stimuli are mandatory for a fine-tuned regulation of cutaneous immune responses and tissue maintenance and repair. They initialize host immune responses, but are equally important for counter regulation of proinflammatory events. Interaction of the nervous and immune systems occurs both locally - at the level of neurogenic inflammation and immunocyte activation - and centrally - by controlling inflammatory pathways such as mononuclear activation or lymphocyte cytokine secretion. Consequently, a deregulated neurogenic immune control results in disease manifestation and frequently accompanies chronic development of cutaneous disorders. The current understanding, therapeutic options, and open questions of the role that neuropeptides such as substance P, calcitonin gene-related peptide, vasoactive intestinal peptide/pituitary adenylate cyclase-activating polypeptide, neuropeptide Y, or others play in these events are discussed. Progress in this field will likely result in novel therapies for the management of diseases characterized by deregulated inflammation, tissue remodeling, angiogenesis, and neoplasm.

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27. Glucocorticoid Regulation of Hair Growth in Alopecia Areata

Author

Marty E. Sawaya and Maria K. Hordinsky

Subjects
medicine.medical_specialty, Thioredoxin-Disulfide Reductase, Alopecia Areata, education, Dermatology, Biochemistry, Hair growth, Receptors, Glucocorticoid, Calmodulin, Internal medicine, medicine, Humans, Receptor, skin and connective tissue diseases, Glucocorticoids, Molecular Biology, health care economics and organizations, Scalp, integumentary system, business.industry, Alopecia, Cell Biology, Alopecia areata, medicine.disease, body regions, Endocrinology, Case-Control Studies, Glucocorticoid metabolism, Calcium, business, Glucocorticoid, Hair, medicine.drug
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