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Start Over Author "Wei, Qingyi" Journal journal of investigative dermatology
18 results on '"Wei, Qingyi"'

11. Melanoma Expression Genes Identified through Genome-Wide Association Study of Breslow Tumor Thickness

Author

Fang, Shenying, Vaysse, Amaury, Brossard, Myriam, Wang, Yuling, Deng, Defeng, Liu, Quan, Zhang, Peter, Xu, Kejing, Li, Ming, Feng, Runhua, Liu, Huey, Dang, Yifang, Chen, Wei, Prieto, Victor, Gershenwald, Jeffrey E., Ross, Merrick I., Matejka, Brenna, Malke, Jared, Haydu, Lauren E., Reveille, John D., Sui, Dawen, Bassett, Roland L., Jr., Koshkina, Nadya, Avril, Marie Françoise, Lu, Mason, Wei, Qingyi, Demenais, Florence, Amos, Christopher I., and Lee, Jeffrey E.

Published
2017
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14. Genetic Variants in WNT2Band BTRCPredict Melanoma Survival

Author

Shi, Qiong, Liu, Hongliang, Han, Peng, Li, Chunying, Wang, Yanru, Wu, Wenting, Zhu, Dakai, Amos, Christopher I., Fang, Shenying, Lee, Jeffrey E., Han, Jiali, and Wei, Qingyi

Abstract

Cutaneous melanoma (CM) is the most lethal skin cancer. The Wnt pathway has an impact on development, invasion, and metastasis of CM, thus likely affecting CM prognosis. Using data from a published genome-wide association study from The University of Texas MD Anderson Cancer Center, we assessed the associations of 19,830 common single-nucleotide polymorphisms (SNPs) in 151 Wnt pathway autosomal genes with CM-specific survival and then validated significant SNPs in another genome-wide association study from Harvard University. In the single-locus analysis, 1,855 SNPs were significantly associated with CM-specific survival at P < 0.05, of which 547 SNPs were still considered noteworthy after the correction by the false-positive report probability. In the replication, two SNPs remained significantly associated with CM-specific survival after multiple comparison correction. By performing functional prediction and stepwise selection, we identified two independent SNPs (i.e., WNT2Brs1175649 G>T and BTRCrs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41–2.81, P = 8.10 × 10−5) and 0.61 (0.46–0.80, 3.12×10−4), respectively. Collectively, these variants in the Wnt pathway genes may be biomarkers for outcomes of patients with CM, if validated by larger studies.

Published
2017
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