Search

Objectives The purpose of this study is to investigate the trends of Korean medicine treatments of spondylolisthesis. Methods We investigated the studies on Korean medicine treatments for spondylolisthesis via searching 4 Korean web databases (OASIS, KTKP, RISS, DBpia). We used "Spondylolisthesis", "Lumbar spondylolisthesis" as keyword. Limitations were as follows; Domestic studies, mentioning the treatments of spondylolisthesis in Korean medicine. This study researched and classified the papers according to type of study, published year, titles of journals, published institution, the number of cases, and types of treatments. Results 14 research papers were found to be analyzed according to their published year, the titles of journals, published institution, the types of study, the number of cases, and the types of treatments. 14 papers were published since 2000. The studies on Korean medicine treatments about spondylolisthesis were mainly published in the journal of Korean acupuncture & moxibustion medicine. 7 case reports, 6 case series, 1 RCT had been under research. In 14 cases of the studies, various Korean medicine treatments were used to treat the symptoms. Numeric rating scale (NRS) was used as primary assessments. Conclusions In this study, we analyzed the trends of Korean medicine treatments of spondylolisthesis. Reviewing the domestic trends of studies on Korean medicine treatments of spondylolisthesis and examining the strong and weak points of those treatments are essential for the further studies.

Objectives The purpose of this study was to know the effects of Danggwisayeok-tang (Dangguisinitang) extract (DGSYT) on monosodium iodoacetate (MIA)-induced rat osteoarthritis. Methods For this purpose, rats were divided into 5 groups. Normal group was not injected with MIA and orally administered any medication. Control group was injected with MIA and not orally administered any medication. DGSYT100 group was injected with MIA and orally administered 100 mg/kg of DGSYT. DGSYT300 group was injected with MIA and orally administered 300 mg/kg of DGSYT. JoinsT group was injected with MIA and orally administered 20 mg/kg of Joins tablet. DGSYT100 and DGSYT300 groups were orally administered DGSYT during a week before and 3 weeks after based on the day MIA injected. The changes of hepatotoxicity, nephrotoxicity, relative hind paw weight distribution, cytokine in serum, cytokine messenger ribonucleic acid (mRNA) in joint tissue and histopathological observation (Hematoxylin & Eosin and Safranin-O staining) were measured. Results Alanine aminotransferase (ALT) levels of DGSYT100, DGSYT300 and JoinsT groups were increased significantly, but these results were within normal range. Aspartate aminotransferase (AST) and creatinine levels of all groups were not changed significantly. In the change of relative hind paw weight distribution, DGSYT300 and JoinsT groups were decreased significantly 14 and 21 days after MIA injected. Interleukin- (IL-) and Interleukin-6 (IL-6), Leukotriene and Osteocalcin levels of DGSYT300 and JoinsT groups were decreased significantly. In measurement of IL- and nitric oxide synthase-II mRNA relative quantitative of control, DGSYT100, DGSYT300 and JoinsT groups were decreased significantly. In measurement of TNF-, IL-6 and Cyclooxygenase-2 mRNA relative quantitative of control, DGSYT300 and JoinsT groups was decreased significantly. In histopathological observation of knee, synovial tissue, cartilage and proteoglycan of DGSYT100, DGSYT300 and JoinsT were well preserved compared with control group. Conclusions According to the results, DGSYT has anti-inflammation and pain relief effects. So it should be suppressed progression of arthritis in MIA-induced osteoarthritis rat.

Objectives This study was carried out to investigate the effects of Gyejigabuja-tang extracts on the Monosodium iodoacetate (MIA) induced osteoarthritis in rats. Methods Osteoarthritis was induced by injection of MIA into knee joint cavity of rats. Rats are divided into 4 groups (normal, control, positive comparison group, GBT group, each n