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Objective To investigate HPV infection, subtype distribution, and age distribution in females in Kunming. Methods Flow fluorescence hybridization was used to detect HPV genotypes in 6 091 female cervical exserted cells in Kunming Maternal and Child Health Hospital in 2021. Infection rate, gene subtypes and age distribution were obtained after classification and statistics. Results 1 301 people wereinfected with HPV, the infection rate was 21.36%. Single infected persons accounted for the majority (78.94%). In all positive specimens, the number of high-risk infection cases was more than that of low-risk infection cases. The highest infection rates were HPV52 (21.83%), HPV16 （11.38%), and HPV58 (10.76%), respectively. Participants were divided into ≤ 20 years old group, 21 to 30 years old group, 31 to 40 years old group, 41 to 50 years old group, 51 to 60 years old group and > 60 years old group according to age. The HPV infection rate was highest in the > 60 years old group, followed by the 21 to 30 years old group and the 51 to 60 years old group. Conclusions HPV infection in women in Kunming is mainly a hhigh-risk type. Elderly and people under 30 years old need to strengthen prevention and treatment education, and it is recommended that women of appropriate age receive multivalent cervical cancer vaccine as soon as possible. [ABSTRACT FROM AUTHOR]

Objective　To explore the correlation of early serum uric acid fluctuations in patients after the bariatric surgery. Methods　From January 2021 to June 2022，80 patients with the metabolic syndrome who were admitted to Yan'an Hospital of Kunming and completed the follow-up one month after the surgery were selected as the objective of this research experiment.And according to the serum uric acid index one month after the surgery， they were divided into group A with the increase of serum uric acid after the operation and group B with the decrease of serum uric acid after the operation. The BMI value and the changes of various biochemical indexes were compared between the two groups before and after the bariatric surgery. Results　Surgery method， postoperative protein intake，aerobic exercise and water intake were not the reasons for the fluctuation of serum uric acid in patients after weight loss（P > 0.05），and the changes in liver function also could not explain the changes in patients 1 month after weight loss（ P > 0.05） . The changes of blood sugar and triglyceride were the main reasons for the fluctuation of postoperative blood uric acid（P < 0.05）. The greater the decrease in triglycerides after the surgery，the less likely the increase in uric acid will occur.In addition，the increase of blood uric acid at 1 month after operation was greater than the decrease of blood uric acid after the operation，and the change of blood uric acid was correlated with the change of serum creatinine and monocyte/high-density lipoprotein（MHR）（P < 0.05）. The correlation coefficients were 0.204 and 0.511 respectively.respectively. Conclusion　The changes of triglyceride and blood sugar in the early postoperative period are the reasons for the increase or decrease of blood uric acid in patients with weight loss after the surgery，and the changes of blood uric acid are mainly affected by creatinine and monocyte/high density. [ABSTRACT FROM AUTHOR]

Objective To analyze the level of serum 25-hydroxyvitamin D (25OHD) in women of early pregnancy in Kunming Maternal and Child Health Hospital, and to explore the correlation between the level and gestational age, so as to provide suggestions for reasonable vitamin D supplement for women planning pregnancy. Methods From January 2018 to December 2020, 4 283 pregnant women in Kunming Maternal and Child Health Hospital were selected as the observation subjects. They were divided into 16 to 20 years old group (97 cases), 21 to 25 years old group (999 cases), 26 to 30 years old group (1 894 cases), 31 to 35 years old group (930 cases), 36 to 40 years old group (303 cases). 41 to 45 years old group (60 cases) 6 groups. The serum 25- hydroxyvitamin D levels of 6 groups of pregnant women were compared. Results The average level of vitamin D in 4 283 pregnant women was lower than normal, and the level of 25OHD in 16 ～20 years old group was the lowest. Conclusion Gestational age is correlated with serum 25OHD level, and the serum 25OHD level in the low gestational age group is relatively low, which requires early screening and intervention for the level of 25OHD in the low gestational age women. [ABSTRACT FROM AUTHOR]

Objective To compare the effectiveness of laparoscopy- assisted gastrectomy （LAG） and open gastrectomy（OG） for advanced distal gastric cancer （ADGC） . Methods 56 patients with advanced distal gastric cancer from our hospital were divided into LAG group and OG group （n＝28），and each group was performed LAG and OG respectively. Operation situation， intraoperative blood loss，the number of dissected lymph nodes，postoperative passage of flatus，postoperative hospital stay and postoperative complications were observed in two groups. Results Operation time of patients was significantly longer in LAG group than OG group， but intraoperative blood loss，postoperative hospital stay， postoperative passage of flatus and postoperative complication rates were significantly lower in LAG group compared with OG group （P < 0.05） . There were no statistical differences in lymph node dissection between the two groups（P > 0.05） . Conclusion LAG had the benefits of smaller trauma， less intraoperative blood loss， faster postoperative recovery， shorter hospital stay and lower incidence of postoperative complications for surgical treatment of patients with ADGC. Therefore， LAG is suggested to be used as the first choice method for surgical treatment of this disease. [ABSTRACT FROM AUTHOR]