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Objective To analyze the nutrition knowledge and attitudes and factors associated with dietary nutrition literacy of Ji Nuo, Jing Po, De Ang, A Chang, Bu Lang and Pu Mi ethnic minorities in Yunnan Province from January 2018 to August 2020. Methods The data were collected by multi-stage stratified cluster sampling in the six ethnic minorities areas of Yunnan Province. The total of 3 145 ethnic minorities aged ≥18 years were investigated the nutrition knowledge. The chi-square test and logistic analysis were done by SAS9.4 software. Results All the nutrition knowledge among the number of 3 145 ethnic minorities aged 18 years and above in Yunnan province had a median score of 8.7. The percentage of 8.3% of them had adequate dietary nutrition literacy, which was significant among different ethnic groups (χ² = 149.974, P < 0.0001) . The lowest percentage was 0.2% among Bu Lang people. Higher education levels were associated with higher literacy of dietary nutrition (OR = 1.992, OR = 3.073, P < 0.05, compared with primary school and below education level). Ji Nuo, De Ang, Bu Lang and Pu Mi people did not have adequate dietary nutrition literacy compared with A Chang people (OR = 0.105, OR = 0.366, OR = 0.010, OR = 0.341, P < 0.05). Conclusion The awareness of dietary nutrition knowledge and literacy were at a low level among six ethnic minorities aged 18 years and above in Yunnan province. The propaganda and education of dietary nutrition knowledge should be strengthened, especially the ethnic minorities with low education level so as to improve adequate literacy. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical characteristics of 53 cases of congenital hyperbilirubinemia (Gilbert syndrome, Crigler-Najjar syndrome) caused by UGT1A1 gene mutation in Yunnan Province and the characteristics of UGT1A1 gene mutation. Methods 53 cases were selected from the Department of Gastroenterology of Kunming Children’ s Hospital from January 2017 to December 2022 and divided into Gilbert syndrome (GS) group and Crigler-Najjar-2 (GN-2)group. The clinical data and genetic test results of children with type I1 syndrome (CN-2 group)and the clinical manifestations, laboratory test results and gene polymorphisms of the children were retrospectively analyzed. Results Children from the ethnic minority had the higher incidence in both groups. The proportion of females in CN-2 group was higher than that in GS group. In terms of liver system, the levels of TBil and IDB in CN-2 group were higher than those in GS group, with statistical significance (all P values < 0.05). The liver structure in GS group was normal, while 3 patients in CN-2 group had the abnormal liver and biliary structure. In the extra-hepatic system, there were no abnormalities in blood system and glucose metabolism, abnormal blood lipids and thyroid function metabolism, vitamin D deficiency in GS group, vitamin A and D deficiency and vitamin E decreased in CN-2group. There were cardiac structural abnormalities in both groups, but the incidence of CN-2 group was higher than that of GS group. Among all the patients, the mutation frequency of c.1456T>G in exon 5 was the highest (32 cases, 60.37%), followed by c.1091C>T (14 cases, 60.37%). Exon 1, C.211g>A (6 cases, 11.32%), and C.1198a >C (4 cases, 7.55%). The frequency of c.1456T>G mutation in GS group and CN-2 group was 69.23% and 57.5%（9 and 23 cases), respectively, and there was no significant difference between the two groups (P > 0.05). Among the two groups, the second most frequent mutation was c.1091C>T (4 cases and 10 cases), and there was no statistical significance between the two groups (P > 0.05).The frequencies of UGT1A1 haplotypes 1、3 and 4 were statistically significant between GS group and CN-2 group (P < 0.05). There is no significant difference in gender and ethnic groups among the four major mutation forms of UGT1A1 (P > 0.05). Conclusion The clinical manifestations of the liver system and [ABSTRACT FROM AUTHOR]

Objective To assess the nutritional status of vitamin A among adults of ethnic minority groups native to Yunnan Province, and provide scientific evidence for healthy eating promotions. Methods Between 2016 and 2020, 841 adults were randomly sampled from seven ethnic minority groups according to the sex and age composition in the 6thnational census. The serum retinol level was determined using high-performance liquid chromatography (HLCP), and judged by the WHO criteria. Vitamin A intake was calculated through a dietary survey and judged by reference to the dietary guidelines. Results The median serum vitamin A concentration was 0.55 mg/L (ranging from 0.44 to 0.68 mg/L) and significant differences were found in sex, race, education and income levels (all P < 0.05). The prevalence of vitamin A deficiency and marginal deficiencies were 0.7% and 3.7%, respectively. The median of dietary vitamin A intake was 406.0 µg retinol equivalents (RE) and 67.0% of the subjects consumed less vitamin A than the Chinese Estimated Average Requirement (EAR). The major food sources of vitamin A were dark vegetables, eggs, light vegetables and meat, accounting for 86.6% of total vitamin A intake. Conclusion The serum vitamin A concentration is relatively good in the population, whereas inadequate vitamin A intake remains a problem, especially for certain ethnic groups, older and poor adults. [ABSTRACT FROM AUTHOR]

Objective To provide reference for clinical rational use of vancomycin through analyzing the monitoring results of vancomycin plasma concentration in patients with intracranial infection or/and pulmonary infection after neurosurgery in our hospital. Methods We collected the related information of 119 neurosurgical patients with intracranial infection and/or pulmonary infection, and the monitoring results of vancomycin blood concentration and the influencing factors were analyzed. Results With the dosage of vancomycin 1g, IVGTT, q12h, only 26.1% of the patients were within the reference range （10-20 mg/L）and 68.1% were lower than the reference range. Multiple linear regression analysis showed that only creatinine clearance rate had significant effect on the trough concentration of vancomycin. Conclusion When patients with postoperative infection in neurosurgery are treated with vancomycin, the dosage of 1g, IVGTT, q12h may not reach the effective blood concentration, so the initial dosage should be selected according to the creatinine clearance rate of patients, and the blood concentration of vancomycin should be closely monitored, and the dosage regimen should be adjusted according to the situation of patients and the detection results timely. [ABSTRACT FROM AUTHOR]

Methamphetamine is a serious threat to public health and safety of mental excitatory drugs. Longterm abuse of METH will cause obvious neuronal injury and neurotoxicity. Oxidative stress, mitochondrial metabolic damage and neuroinflammation play important roles in meth-induced neuronal injury. In this paper, we reviewed the mechanism of neuronal injury induced by METH and the neurotoxicity mechanism of METH. The neuroinflammatory effect of reactive glial cells is described in detail, and the neuroinflammatory drugs induced by targeted METH are summarized. This article aims to further explore the mechanism of meth-induced neurotoxicity and provide new ideas for inhibiting meth neurotoxicity and drug development. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the detection value of peripheral blood miR related indexes in the patients with silicosis. Methods 98 patients with silicosis from February 2015 to June 2018 were selected as the observation group，98 healthy people with physical examination at the same time were selected as the control group.Then the peripheral blood miR related indexes （miR-222，miR-155，miR-29a and miR-204） of two groups were detected and compared，then the detection results of observation group with different stages and classifications were compared，and the correlations between those peripheral blood indexes and silicosis were analyzed with Spearman rank correlation analysis. Results The peripheral blood miR-222 and miR-29a of observation group were higher than those of control group，the miR-155and miR-204 were lower than those of control group，and the detection results of observation group with different stages and classifications were compared，the differences were all statistically significant（P ＜0.05） . The Spearman rank correlation analysis showed that the peripheral blood miR-222 and miR-29a were positively correlated with silicosis，but miR-155 and miR-204 were negatively correlated with silicosis（P＜0.05）. Conclusion The detection value of peripheral blood miR related indexes in the patients with silicosis are higher，and it has certain reaction role for the severity of silicosis. [ABSTRACT FROM AUTHOR]

Objective To obtain the pass rate of driving test of monocular visually impaired patients in Yunnan province and analyze the cause of monocular visually impaired patients．Methods We performed Visual acuity， computer Optometry， horizontal visual field， color vision and slit-lamp microscope on each of the physical participants. In this survey， 294 people who had undergone medical examinations from January 2018 to April 2018 were divided into three groups for retrospective analysis by age. The uncorrected distance visual acuity of the superior eye or corrected distance visual acuity reaches the logarithmic vision table 5.0 and above， the horizontal field of vision reaches 150 °， and there is no red-green blind person who passes the medical examination. The statistical method uses SPSS19 .0 statistical software， mainly descriptive statistics．Results 250 males and 44 females were included in the analysis. The ratio of males to females was 5:1. Age 18-60 years old， average age 32 ± 8 years old. The overall pass rate for medical examinations was 69.4 %，68.8%for men and 72.7%for women. The lowest pass rate for men and women is over 40 years old （χ2 =12.676，P＜0.001 and χ2 =11.092，P=0.001） ; The pass rate of men gradually decreases with age. Among the causes of monocular vision disorders， 148 male eye injuries， 68 amblyopia， and 34 others; Female eye trauma 7， amblyopia 29， other 8. Most of the injuries occurred in young age， including 96 sharp injuries， 48 bullet injuries， and 11 explosive injuries．Conclusion At present， the pass rate of the one-eye vision impairment driver's license in our province is 69.4 %. Among the causes of monocular vision disorders， the most important male eye trauma in early childhood， followed by the failure to detect and treat amblyopia in time; The most important female amblyopia is not found and treated in time. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the mutation of hemagglutinin gene and amino acid variation of influenza B. Methods Influenza B virus was isolated from throat swab samples in sentinel surveillance of Yunnan province from 2009 to 2014. HA1 gene sequence analysis was applied to determine 12 randomly-selected strains of influenza B virus. The results were analyzed，MEGA software was used to do homology comparison and HA gene phylogenetic tree was established．Results Differences on the serotype and genotype identification of influenza strains were found and it might be caused by inadequate gene mutation accumulation. Amino acid variations were found in 3 important regions of antigenic determinants in HA1 protein: ring 120, ring 150 and ring 160. The amino acid variation of position 131 in ring 120 was N131K, and in position 137 was N137H. Two strains had P187S mutation in position 187. Conclusion There are some important variations in the hemagglutinin gene of influenza B strains in Yunnan Province，with some variations being the same as vaccine strains and some being not. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To understand the viral etiology of acute respiratory infection in Kunming area. Methods We collected the nasopharyngeal swab of patients with acute respiratory tract infection，and used multiple reverse transcription-polymerase chain reaction （RT-PCR） method to detect 15 kinds of respiratory viral pathogens. Results Among the 600 samples，144 strains of viruses were detected， the positive rate was 24%，among which the highest positive rate was RSV （49/600，8.2%），followed by PIV （32/600，5.3%） HRV （27/600，4.5%） and IFV27 （27/600，4.5%） . The respiratory virus infection situation was different in every age group， groups of the highest virus positive rate was ≤1 age group （72/216，33.3%）；The respiratory virus infection situation in different seasons was different， the virus positive rate of the first quarter was the highest （85/144， 59%） . Conclusion RSV was the main virus pathogen of acute respiratory tract infections in Kunming area in 2011 years， the detection rate in sick children was the highest among all patients; the detection rate in the first quarter was higher than other quarters. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To analyze the fundus characteristics and fluorescein angiography of morning glory syndrome．Methods The morning glory syndrome patients' fundus photography and fundus fluorescein angiography were analyzed in our hospital．Results Fundus examination showed: a large disc with a funnel-shaped excavation surrounded by an annulus of choriorretinal atrophy. A white tuft of glial tissue overlies the central portion of disc. The blood vessels emerged from the rim of excavation in a radial pattern，and they increased in number and it was difficult to distinguish arteries fromveins. Angiographic characteristics: in the central of disc the white tissue was blockage of fluorescence or hypofluorescence which was surrounded by is hyperfluorescence， and at the outside is transmitted fluorescence. It's rarely to see fluorescein leakage．Conclusion The fundus examination， fundus fluorescein angiography and combination of patients' history are helpful to confirm the diagnosis of morning glory syndrom. [ABSTRACT FROM AUTHOR]