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Start Over Author "L. V. Gavrilina" Journal journal of labelled compounds and radiopharmaceuticals
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1. Use of HPLC for increasing the molar specific activities of tritium-labelled nucleosides

Author

L. V. Gavrilina, Yu. L. Kaminski, and B. K. Kudelin

Subjects
Chromatography, Chemistry, Elution, Organic Chemistry, Fractionation, Reversed-phase chromatography, Ribonucleoside, Biochemistry, High-performance liquid chromatography, Analytical Chemistry, Drug Discovery, Kinetic isotope effect, Radiology, Nuclear Medicine and imaging, Specific activity, Tritium, Spectroscopy
Abstract

The possibility of chromatographic separation of different isotopic forms of tritiated nucleosides has been demonstrated. Using a reversed-phase column in 3–5% solutions of ethanol in water the labelled nucleosides eluted ahead of corresponding unlabelled analogs. Such isotope effects allow simultaneous fine purification of nucleosides and its fractionation according to molar specific activity value.

Published
1992
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