1. Type I diabetes mellitus decreases in vivo macrophage-to-feces reverse cholesterol transport despite increased biliary sterol secretion in mice
- Author
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Uwe J. F. Tietge, Jelske N. van der Veen, Markus van der Giet, Folkert Kuipers, Jan Freark de Boer, Marijke Schreurs, Wijtske Annema, Niels Nijstad, Faculteit Medische Wetenschappen/UMCG, Center for Liver, Digestive and Metabolic Diseases (CLDM), and Lifestyle Medicine (LM)
- Subjects
endocrine system diseases ,neutral sterols ,Fatty Acids, Nonesterified ,ANTIINFLAMMATORY PROPERTIES ,Biochemistry ,chemistry.chemical_compound ,Feces ,Mice ,Endocrinology ,High-density lipoprotein ,cardiovascular disease ,OXIDATIVE STRESS ,glucose ,Phospholipids ,Research Articles ,Reverse cholesterol transport ,efflux ,Cholesterol ,Liver ,CARDIOVASCULAR-DISEASE ,Cardiovascular Diseases ,Intestinal cholesterol absorption ,SELECTIVE UPTAKE ,lipids (amino acids, peptides, and proteins) ,high density lipoproteins ,PRACTICE RESEARCH DATABASE ,medicine.medical_specialty ,Lipoproteins ,DEPENDENT VASORELAXATION ,bile ,QD415-436 ,Biology ,Real-Time Polymerase Chain Reaction ,Models, Biological ,Diabetes Mellitus, Experimental ,Excretion ,Bile Acids and Salts ,In vivo ,Internal medicine ,medicine ,Animals ,Scavenger receptor ,bile acids ,BILE-ACID METABOLISM ,APOLIPOPROTEIN-A-I ,Macrophages ,nutritional and metabolic diseases ,Biological Transport ,Cell Biology ,Sterol ,PHOSPHOLIPASE A(2) ,Mice, Inbred C57BL ,Diabetes Mellitus, Type 1 ,chemistry ,atherosclerosis ,HIGH-DENSITY-LIPOPROTEIN - Abstract
Type I diabetes mellitus (T1DM) increases atherosclerotic cardiovascular disease; however, the underlying pathophysiology is still incompletely understood. We investigated whether experimental T1DM impacts HDL-mediated reverse cholesterol transport (RCT). C57BL/6J mice with alloxan-induced T1DM had higher plasma cholesterol levels (P
- Published
- 2012