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Start Over Author "Karen L. Williams" Journal journal of liquid chromatography
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1. Determination of Enantiomers in Human Serum by Direct Injection onto a β-Cyclodextrin HPLC Bonded Phase

Author

Karen L. Williams and Apryll M. Stalcup

Subjects
chemistry.chemical_classification, Analyte, animal structures, Chromatography, Cyclodextrin, Elution, organic chemicals, Diol, High-performance liquid chromatography, chemistry.chemical_compound, chemistry, Phase (matter), polycyclic compounds, Molecular Medicine, heterocyclic compounds, Enantiomer, Analysis method, circulatory and respiratory physiology
Abstract

A method is proposed for the direct enantiomeric analysis of chiral drugs in human serum by HPLC. The method is based on a commercially available β-cyclodextrin bonded phase which incorporates diol as well as cyclodextrin moieties. The proteinaceous components of the serum, which are shown to elute with the void volume, are well separated from the enantiomeric analytes. This allows for the rapid determination of the enantiomeric composition of the drugs.

Published
1992
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