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• Inclined magnetization and Bioconvection effects are investigated. • Prandtl mixture based hybrid nanofluid model has been utilized to investigate heat transfer over stretched surface. • Motile Micro-organisms migration has been examined with convective condition. • Enhanced Nusselt number and reduced shear stress coefficients are explored. Keeping in view the applications of the hybrid nanofluids in the engineering and industries such as heating and cooling, food processing and heat generation, the focus of this investigation is to explore the effect of mixture base hybrid nanofluid with bio convection effect over linearly convectively heated stretched surface due to the motile micro organisms. The high thermal conductivity of the hybrid nanofluid play significant role in heat transmission. The effect of inclined magnetization on heat transfer of the hybridized bioconvective flow is also examined in this study. Prandtl hybrid nanofluid is used along with silver and magnetite nano-particles. The flow governing equations have been converted into dimensionless form through a suitable similarity transfer. The flow governing model equations are highly non linear and can't be tackled analytically. Therefore, the formulated problem has been addressed using the BVP-4C technique. It was observed that when inclination angle of the magnetization is kept at 60 degrees and magnetic force is in the range of 0.5 < M ≤ 4 , the velocity profile increase. Raising the level of bioconvection impact decline microorganism migration, on contrary high levels of Peclet number reverse this effect. Significant improvement has been observed in heat transfer shift and shear stress by raising thermal Biot number. The outcomes of the present study have been validated with already published results, the outcomes of our results were found in good agreement with previously published results. [ABSTRACT FROM AUTHOR]