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Construction operations in airport expansion projects often attract wildlife species to critical airport traffic areas leading to an increase in the risk of wildlife-aircraft collision accidents. Airport operators and construction planners need to carefully consider and minimize these wildlife hazards during the planning of construction site layouts in order to comply with Federal Aviation Administration recommendations. This paper presents the development of an advanced optimization model for planning airport construction site layouts that is capable of minimizing the hazards of wildlife attractants and minimizing the site layout costs, simultaneously. The model incorporates newly developed concepts and performance criteria that enable (1) quantifying, controlling, and minimizing the hazards of construction-related wildlife attractants near airport traffic areas; and (2) minimizing the travel cost of construction resources and the cost of devices installed to control wildlife on airport construction sites, while complying with all relevant aviation safety constraints. The model is developed using a multiobjective genetic algorithm and an application example is analyzed to demonstrate the use of the model in optimizing airport construction site layouts and its unique capability of generating optimal trade-offs between wildlife control and site layout costs. DOI: 10.1061/(ASCE)0742-597X(2006)22:4(176) CE Database subject headings: Optimization; Computation; Safety; Airport construction; Construction sites; Site evaluation; Site preparation; Wildlife.