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Your search keyword '"Nathanael Leung"' showing total 2 results
Start Over Author "Nathanael Leung" Journal journal of materials research and technology
2 results on '"Nathanael Leung"'

1. Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model

Author

Jingyi Mo, Nathanael Leung, Priyanka Gupta, Bin Zhu, Hui Xing, Jiao Zhang, Eirini Velliou, and Tan Sui

Subjects
Bioinspired polyurethane, Surface functionalisation, Synchrotron X-ray techniques, in situ mechanical testing, Mining engineering. Metallurgy, TN1-997
Abstract

In this work, novel bioinspired polyurethane (PU) scaffolds were fabricated via freeze casting for PU-based Pancreatic Ductal Adenocarcinoma (PDAC) model. In order to reproduce the tumour micro-environment that facilitates cellular kinetics, the PU scaffolds were surface modified with extracellular matrix (ECM) proteins including collagen and fibronectin (Col and FN). Synchrotron-based small- and wide-angle X-ray scattering (SAXS/WAXS) techniques were applied to probe structural evolution during in situ mechanical testing. Strains at macroscopic, nano-, and lattice scales were obtained to investigate the effects of ECM proteins and pancreatic cell activities to PU scaffolds. Significant mechanical strengthening across length scales of PU scaffolds was observed in specimens surface modified by FN. A model of stiffness modulation via enhanced interlamellar recruitment is proposed to explain the multi-scale strengthening mechanisms. Understanding multi-scale deformation mechanisms of a series of PU scaffolds opens an opportunity in developing a novel pancreatic cancer model for studying cancer evolution and predicting outcomes of drug/treatments.

Published
2021
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2. Multi-scale structural and mechanical characterisation in bioinspired polyurethane-based pancreatic cancer model

Author

Nathanael Leung, Priyanka Gupta, Hui Xing, Jiao Zhang, Jingyi Mo, Bin Zhu, Eirini Velliou, and Tan Sui

Subjects
In situ, Materials science, Biomaterials, Extracellular matrix, chemistry.chemical_compound, Surface functionalisation, Pancreatic cancer, Bioinspired polyurethane, Nano, medicine, Strengthening mechanisms of materials, Polyurethane, Mining engineering. Metallurgy, biology, Small-angle X-ray scattering, Synchrotron X-ray techniques, Metals and Alloys, TN1-997, medicine.disease, Surfaces, Coatings and Films, Fibronectin, chemistry, Ceramics and Composites, biology.protein, Biophysics, in situ mechanical testing
Abstract

In this work, novel bioinspired polyurethane (PU) scaffolds were fabricated via freeze casting for PU-based Pancreatic Ductal Adenocarcinoma (PDAC) model. In order to reproduce the tumour micro-environment that facilitates cellular kinetics, the PU scaffolds were surface modified with extracellular matrix (ECM) proteins including collagen and fibronectin (Col and FN). Synchrotron-based small- and wide-angle X-ray scattering (SAXS/WAXS) techniques were applied to probe structural evolution during in situ mechanical testing. Strains at macroscopic, nano-, and lattice scales were obtained to investigate the effects of ECM proteins and pancreatic cell activities to PU scaffolds. Significant mechanical strengthening across length scales of PU scaffolds was observed in specimens surface modified by FN. A model of stiffness modulation via enhanced interlamellar recruitment is proposed to explain the multi-scale strengthening mechanisms. Understanding multi-scale deformation mechanisms of a series of PU scaffolds opens an opportunity in developing a novel pancreatic cancer model for studying cancer evolution and predicting outcomes of drug/treatments.

Published
2021

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