1. Antibiotic peptide-modified nanostructured titanium surface for enhancing bactericidal property.
- Author
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Zhu, Chen, Zhang, Wei-wei, Fang, Shi-yuan, Kong, Rong, Zou, Gang, Bao, Ni-Rong, Zhao, Jian-Ning, and Shang, Xi-Fu
- Subjects
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ANTIBIOTICS , *NANOSTRUCTURED materials , *BACTERICIDAL action , *BIOMATERIALS , *ORTHOPEDIC surgery , *SURGICAL complications - Abstract
The infections associated with titanium-based biomaterials have been one of the most serious postoperative complications in the orthopedic surgery. Great efforts have been made to improve the antimicrobial property of titanium-based biomaterials by virtue of the surface modification strategy. From the biomimetic perspective of vegetation roots anchoring soil, alkali treatment was conducted on metallic titanium to produce a nanoroot-structured surface in the present study; then, antimicrobial peptide was anchored within the nanoroot surface by vacuum extraction and lyophilization. As a result, the obtained antibacterial peptide-leashed titanium surface showed a hierarchical structure combining the designed nanoroot topography and the anchored antibiotic peptide. Furthermore, this modified surface could steadily release for more than 10 h in a time-dependent manner. As a consequence, the elaborate antimicrobial peptide-loaded surface demonstrated a powerful antibacterial and biofilm-resistant capability against two types of
Staphylococcus , without significant cytotoxicity. Specifically, Peptide-2 can kill the most planktonic and sessile bacteria for two gram-positive bacteria. Therefore, the integration of antibacterial peptide onto titanium-based implant surface may be a hopeful tool to prevent implant-associated infections in the orthopedic surgery. [ABSTRACT FROM AUTHOR]- Published
- 2018
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