1. In vitro cytocompatibility of triclosan coated Polyglactin910 sutures.
- Author
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Ji H, Zhang Z, Wang C, Li X, Zhang G, and Liu D
- Subjects
- Humans, Hemolysis drug effects, Antioxidants pharmacology, Antioxidants chemistry, Biocompatible Materials chemistry, Nitric Oxide metabolism, Cell Survival drug effects, Sutures, Triclosan pharmacology, Triclosan chemistry, Polyglactin 910 chemistry, Materials Testing, Coated Materials, Biocompatible chemistry, Coated Materials, Biocompatible pharmacology, Human Umbilical Vein Endothelial Cells, Cell Proliferation drug effects
- Abstract
Bioabsorbable sutures can improve the medical functions of existing non-absorbable sutures, and may produce new medical effects, and are expected to become a new generation of medical degradable materials. In this study, the cytocompatibility of triclosan coated polyglactin910 sutures (CTS-PLGA910) was analyzed and different concentrations of sutures were prepared. The effects of sutures on the cytotoxicity and cell proliferation of HUVEC were studied by CCK-8 assay. The hemolysis, total antioxidant capacity (T-AOC) activity and nitric oxide (NO) content were investigated to improve the blood compatibility of sutures. The results showed that the hemolysis rate of CTS-PLGA910 was less than 5%. After treatment on HUVEC cells for 48 and 72 h, there was no significant change in NO content in CTS-PLGA910 groups compared with the control group, while T-AOC activity and antioxidant capacity were significantly increased in medium and high dose groups. In summary, the blood compatibility and cell compatibility were significantly improved, which provided a basis for the clinical application of sutures in the future., (© 2024. The Author(s).)
- Published
- 2024
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