1. Determining a cutoff for fetal lung maturity with lamellar body count testing.
- Author
-
Janicki, Mary Beth, Dries, Lisa M., Egan, James F. X., and Zelop, Carolyn M.
- Subjects
- *
NEONATAL diseases , *LUNG disease diagnosis , *RESPIRATORY distress syndrome , *GESTATIONAL diabetes , *PEDIATRIC hematology , *RECEIVER operating characteristic curves - Abstract
Objective. A lamellar body count (LBC) ≥50,000/μl is suggested to document fetal lung maturity (FLM). We sought to determine the LBC threshold for FLM with the Cell-dyn 4000 hematology analyser. Methods. We queried our database for patients who underwent LBC testing from 2001 to 2007. Included were deliveries between 35 and 38 weeks gestation with testing ≤7 days from delivery. We excluded twins, anomalies and cases of ruptured membranes. Data were analysed for sensitivity and specificity of predicting respiratory distress syndrome (RDS) and plotted on a receiver operating characteristic curve. Results. There were 209 patients meeting study criteria. Of these, 120 had diabetes. Five neonates experienced RDS, all born to non-diabetic mothers with LBC values ≤72,000/μl. At this value the sensitivity is 100%, false positive rate 18% and the p value is 0.0146. Conclusion. Our results question the 50,000/μl threshold and demonstrate the need for hematology analyser specific thresholds. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF