1. The impact of fetal gender and ethnicity on the risk of spontaneous preterm delivery in women with symptoms of preterm labor
- Author
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Jérôme Cornette, Femke F. Wilms, Frank P.H.A. Vandenbussche, Caroline J. Bax, Bas W.A. Nij Bijvanck, Jim van Eijck, Martijn A. Oudijk, Hubertina C.J. Scheepers, Kitty W.M. Bloemenkamp, Johannes J. Duvekot, Martina Porath, Jolande Y. Vis, Brent C. Opmeer, Marc E. A. Spaanderman, Antoinette C. Bolte, Anneke Kwee, Maureen T.M. Franssen, Patrick M.M. Bossuyt, Joris A. M. van der Post, Krystyna M. Sollie, Gert Jan Van Baaren, Mallory Woiski, Ben W.J. Mol, Obstetrics & Gynecology, Reproductive Origins of Adult Health and Disease (ROAHD), Obstetrie & Gynaecologie, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), RS: GROW - R4 - Reproductive and Perinatal Medicine, Other departments, Obstetrics and Gynaecology, Epidemiology and Data Science, and Clinical Research Unit
- Subjects
Male ,PREDICTION ,CERVICAL LENGTH ,Fetal Development ,0302 clinical medicine ,DISPARITIES ,Pregnancy ,Epidemiology ,Ethnicity ,EPIDEMIOLOGY ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,GESTATIONAL-AGE ,reproductive and urinary physiology ,030219 obstetrics & reproductive medicine ,Obstetrics ,Obstetrics and Gynecology ,Gestational age ,ASSOCIATION ,Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] ,Premature birth ,Cohort ,embryonic structures ,Premature Birth ,Female ,SEX ,fetal gender ,preterm delivery ,Adult ,Risk ,preterm labor ,medicine.medical_specialty ,BIRTH ,FIBRONECTIN ,Gestational Age ,White People ,03 medical and health sciences ,Obstetric Labor, Premature ,Sex Factors ,medicine ,Journal Article ,Humans ,COHORT ,Sex Distribution ,Gynecology ,Fetus ,Chi-Square Distribution ,business.industry ,Other Research Radboud Institute for Health Sciences [Radboudumc 0] ,medicine.disease ,Fibronectins ,Cervical Length Measurement ,Pediatrics, Perinatology and Child Health ,business ,Chi-squared distribution - Abstract
Contains fulltext : 171740.pdf (Publisher’s version ) (Closed access) OBJECTIVE: The objective of this study is to evaluate the relation among fetal gender, ethnicity, and preterm labor (PTL) and preterm delivery (PTD). METHODS: A secondary analysis was performed of a prospective cohort study including women with symptoms of PTL between 24 and 34 weeks. The proportion of women carrying a male or female fetus at the onset of PTL was calculated. Gestational age at delivery and risk of PTD of both fetal genders was compared and interaction of fetal gender and maternal ethnicity on the risk of PTD was evaluated. RESULTS: Of the 594 included women, 327 (55%) carried a male fetus. Median gestational age at delivery in women pregnant with a male fetus was 37 5/7 (IQR 34 4/7-39 1/7) weeks compared with 38 1/7 (IQR 36 0/7-39 5/7) weeks in women pregnant with a female fetus (p = 0.032). The risk of PTD did not differ significantly. In Caucasians, we did find an increased risk of PTD before 37 weeks in women pregnant with a male fetus (OR 1.9 (95% CI 1.2-3.0)). CONCLUSIONS: The majority of women with PTL are pregnant with a male fetus and these women deliver slightly earlier. Race seems to affect this disparity.
- Published
- 2016