1. Effects of Maternal Diabetes on rat’s Offspring Plasma Ghrelin
- Author
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Ghasem Ivar, Zahra Ghiravani, Faezeh Rezaei, Somayeh Yousefi, Erfan Lotfi, and Mehran Hosseini
- Subjects
maternal diabetes ,offspring ,sexual dimorphism ,ghrelin ,rat ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background and purpose: Ghrelin, a natural ligand of the growth hormone secretagogue receptor plays a major role in regulation of appetite, body fat mass, and energy balance in the body. The aim of this study was to evaluate the effects of maternal diabetes on circulatory ghrelin levels in rat newborns. Materials and methods: In this experimental study, female Wistar rats were allocated into diabetic (n=20) and control (n=10) groups and mated with males. After parturition, 16 offspring (8 males) were collected at both postnatal days (P), P7 and P14. The body weight, blood glucose and plasma ghrelin levels were measured. Data were analyzed applying two-way ANOVA using sex and group as the factors in SPSS V22. Results: At both P7 and P14, the body weight of newborns of diabetic mothers (18.49± 0.42g, 22.27± 0.43g respectively) were significantly lower (P
- Published
- 2018