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Brain tumor segmentation from magnetic resonance (MR) image is vital for both the diagnosis and treatment of brain cancers. To alleviate noise sensitivity and improve stability of segmentation, an effective hybrid clustering algorithm combined with fast guided filter is proposed for brain tumor segmentation in this paper. Preprocessing is performed using adaptive Wiener filtering combined with a fast guided filter. Then simple linear iterative clustering (SLIC) is utilized for pre-segmentation to effectively remove scatter. During the clustering, K-means + + and Gaussian kernel-based fuzzy C-means (K + + GKFCM) clustering algorithm are combined to segment, and the fast-guided filter is introduced into the clustering. The proposed algorithm not only improves the robustness of the algorithm to noise, but also improves the stability of the segmentation. In addition, the proposed algorithm is compared with other current segmentation algorithms. The results show that the proposed algorithm performs better in terms of accuracy, sensitivity, specificity and recall. [ABSTRACT FROM AUTHOR]