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Innovation in pharmaceutical science has become a particular concern for individual health. For a long time, the practice of "One-Size-Fits-All" medication has been common in healthcare services worldwide, making analytical methods crucial to drug analysis in biological matrices. Suitable methods for determining drug levels in biological matrices aim to prevent medication dosage errors. Every person's condition is different, and their diseases vary, caused by genetics, environment, and lifestyle. Personalized medicine is often described as "the right patient, the right drug, at the right dose, at the right time." This study used a qualitative literature review method, where sources or literature in national and international journals were searched through online media. The analysis results explain that the role of the biological environment is more significant than others in vector-borne diseases, and the role of the genetic nucleus is more significant than others in hereditary diseases. Due to the numerous ecological interactions, we can often change the spread of disease by changing certain aspects of human interaction with their environment without direct intervention in the cause of the disease. The implementation of the science from "Bench to bedside" and "From clinic to community" assumes the provision of long-distance healthcare services by healthcare professionals using information technology, where the implementation of telemedicine (Systematic Review) in healthcare services is crucial, considering some of the problems that arise from manual services. One of the technical implementations of telemedicine is to optimize personalized medicine, which also involves implementing pharmacogenetics approaches in hospitals.