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Start Over Author "Yan Lau" Journal journal of medical genetics
4 results on '"Yan Lau"'

1. Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes

Author

Jamil Omar, Mohamad Nasir Shafiee, Meow-Keong Thong, Daren C Y Teoh, Zatul Akmar Ahmad, Chun Sen Lim, Joanna Lim, Nellie Cheah, Angela George, Joseph K Joseph, Yeung Sing Chin, Soo-Hwang Teo, Doris S Y Chow, Badrul Zaman Abdullah, Eveline M. A. Bleiker, Boom Ping Khoo, Shahila Tayib, Teck Sin Tan, Suguna Subramaniam, Chee Kin Fong, Matin Mellor Abdullah, Soo Fan Ang, Yoke Ching Foo, John Low, Rakesh Raman, Yin Ling Woo, Kwong Sheng Loo, Siu Wan Wong, Ahmad Muzamir Ahmad Mustafa, Keng Joo Lim Lim, Sook-Yee Yoon, Nor Huda Mat Ali, Kean Fatt Ho, Kavitha Rethanavelu, Pei Jye Voon, Nur Tiara Hassan, Syuhada Ahmad, Ismail Aliyas, Beng Hock Teh, Mohd Pazudin Ismail, Heamanthaa Padmanabhan, Ileena Muin, Ghazali Ismail, Mastura Md Yusof, Chee Meng Yong, Muzhirah Haniffa, Azura Deniel, Mary Makanjang, Mohamad Faiz Mohamed Jamli, Rozita Abdul Malik, Noor Azmi Mat Adenan, Eunice S E Ong, Lye-Mun Tho, Anuradha Suberamaniam, Lip Hen Moey, Chui Ling Lee, Fuad Ismail, Winnie Peitee Ong, Vickneswaren Ramasamy, Arivendran Raja, Shao Yan Lau, Saw Joo Lee, Zarina Abdul Latiff, Boon Kiong Lim, Suresh Kumarasamy, Wee Teik Keng, Kin Wah Leong, Wee Wee Sim, Swee Kiong Kho, Gwo Fuang Ho, Azura Rozila Ahmad, Paul Hock Oon Ng, Mohd Norazam Mohd Abas, Mohd Rushdan Md Noor, A. B.Ahmad Radzi, Shivaani Mariapun, Gaik-Siew Ch'ng, and Michael C K Lim

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Genetic counseling, Health services research, Health literacy, Mainstreaming, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Patient satisfaction, 030220 oncology & carcinogenesis, Internal medicine, Genetics, medicine, Observational study, business, Psychosocial, Genetics (clinical), Genetic testing
Abstract

BackgroundIdentifying patients with BRCA mutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming.MethodsThe Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer.ResultsOncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1 or BRCA2, and there was no difference between psychosocial measures for carriers in both arms.ConclusionThe MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing.

Published
2021
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2. Oncologist-led

Author

Sook-Yee, Yoon, Siu Wan, Wong, Joanna, Lim, Syuhada, Ahmad, Shivaani, Mariapun, Heamanthaa, Padmanabhan, Nur Tiara, Hassan, Shao Yan, Lau, Gaik-Siew, Ch'ng, Muzhirah, Haniffa, Winnie P, Ong, Kavitha, Rethanavelu, Lip Hen, Moey, Wee Teik, Keng, Jamil, Omar, Mohd Norazam, Mohd Abas, Chee Meng, Yong, Vickneswaren, Ramasamy, Mohd Rushdan, Md Noor, Ismail, Aliyas, Michael C K, Lim, Anuradha, Suberamaniam, Noor Azmi, Mat Adenan, Zatul Akmar, Ahmad, Gwo Fuang, Ho, Rozita, Abdul Malik, Suguna, Subramaniam, Boom Ping, Khoo, Arivendran, Raja, Yeung Sing, Chin, Wee Wee, Sim, Beng Hock, Teh, Swee Kiong, Kho, Eunice S E, Ong, Pei Jye, Voon, Ghazali, Ismail, Chui Ling, Lee, Badrul Zaman, Abdullah, Kwong Sheng, Loo, Chun Sen, Lim, Saw Joo, Lee, Keng Joo Lim, Lim, Mohamad Nasir, Shafiee, Fuad, Ismail, Zarina Abdul, Latiff, Mohd Pazudin, Ismail, Mohamad Faiz, Mohamed Jamli, Suresh, Kumarasamy, Kin Wah, Leong, John, Low, Mastura, Md Yusof, Ahmad Muzamir, Ahmad Mustafa, Nor Huda, Mat Ali, Mary, Makanjang, Shahila, Tayib, Nellie, Cheah, Boon Kiong, Lim, Chee Kin, Fong, Yoke Ching, Foo, Matin, Mellor Abdullah, Teck Sin, Tan, Doris S Y, Chow, Kean Fatt, Ho, Rakesh, Raman, Ahmad, Radzi, Azura, Deniel, Daren C Y, Teoh, Soo Fan, Ang, Joseph K, Joseph, Paul Hock Oon, Ng, Lye-Mun, Tho, Azura Rozila, Ahmad, Ileena, Muin, Eveline, Bleiker, Angela, George, Meow-Keong, Thong, Yin Ling, Woo, and Soo Hwang, Teo

Subjects
BRCA2 Protein, Counseling, Oncologists, Ovarian Neoplasms, BRCA1 Protein, Humans, Female, Genetic Counseling, Genetic Testing, Prospective Studies
Abstract

Identifying patients withThe Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer.Oncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant inThe MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing.

Published
2020

3. Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes.

Author

Sook-Yee Yoon, Siu Wan Wong, Lim, Joanna, Ahmad, Syuhada, Mariapun, Shivaani, Padmanabhan, Heamanthaa, Hassan, Nur Tiara, Shao Yan Lau, Ch'ng, Gaik-Siew, Haniffa, Muzhirah, Ong, Winnie P., Rethanavelu, Kavitha, Lip Hen Moey, Wee Teik Keng, Omar, Jamil, Abas, Mohd Norazam Mohd, Chee Meng Yong, Ramasamy, Vickneswaren, Md Noor, Mohd Rushdan, and Aliyas, Ismail

Abstract

Background Identifying patients with BRCA mutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming. Methods The Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer. Results Oncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1 or BRCA2, and there was no difference between psychosocial measures for carriers in both arms. Conclusion The MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing. [ABSTRACT FROM AUTHOR]

Published
2022
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4. Inherited mutations in BRCA1 and BRCA2 in an unselected multiethnic cohort of Asian patients with breast cancer and healthy controls from Malaysia

Author

Wei Xiong Wen, Jamie Allen, Kah Nyin Lai, Shivaani Mariapun, Siti Norhidayu Hasan, Pei Sze Ng, Daphne Shin-Chi Lee, Sheau Yee Lee, Sook-Yee Yoon, Joanna Lim, Shao Yan Lau, Brennan Decker, Karen Pooley, Leila Dorling, Craig Luccarini, Caroline Baynes, Don M Conroy, Patricia Harrington, Jacques Simard, Cheng Har Yip, Nur Aishah Mohd Taib, Weang Kee Ho, Antonis C Antoniou, Alison M Dunning, and Douglas F

Published
2018
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