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Objective: To compare the antipyretic and cold sponging versus only antipyretic for treatment of fever. Material and Methods: This Randomize control trial was conducted at pediatrics department Khyber Teaching Hospital Peshawar - Pakistan, from August 2017 to December 2017.Total sample of 100 patients were selected randomly for study, written informed consent were taken from parents. Patients were divided into two groups. Group A was given only paracetamol while group B was given paracetamol and cold sponging was also applied, then temperature was checked at 0, 30, 60, 90 and 120 minutes, discomfort was also noted at these intervals. Data was collected by predesigned questionnaire and processed by SPSS 17. Results: Out of total 100 patients 53(53%) were males while 47(47%) females. Mean age was 6.4±2.8 years with minimum of 2 and maximum of 13 years. We had noted that in group B i.e. those who were given antipyretics and applied cold sponging, the decrease of temperature was rapid than those who were given only antipyretics ie. Group A especially in first 30 minutes. Moreover after 2 hours the temperature reached to normal range in both groups but the decrease was more rapid in group B than group A. Conclusion: Fever treated with antipyretic and cold sponging fall faster in the first 30 mint and those treated with only antipyretic the temperature drop was a bit slower but at the end of two hours both reached the same level. [ABSTRACT FROM AUTHOR]