1. Early predictors of clinical deterioration in a cohort of outpatients with COVID‐19 in southern Italy: A multicenter observational study
- Author
-
Caterina, Monari, Mariantonietta, Pisaturo, Paolo, Maggi, Margherita, Macera, Giovanni, Di Caprio, Raffaella, Pisapia, Valeria, Gentile, Mario, Fordellone, Paolo, Chiodini, Nicola, Coppola, Monari, Caterina, Pisaturo, Mariantonietta, Maggi, Paolo, Macera, Margherita, Di Caprio, Giovanni, Pisapia, Raffaella, Gentile, Valeria, Fordellone, Mario, Chiodini, Paolo, and Coppola, Nicola
- Subjects
Adult ,Male ,Clinical Deterioration ,Fever ,SARS-CoV-2 ,SARS-CoV-2 infection ,severe outcome ,COVID-19 ,Middle Aged ,Cohort Studies ,Hospitalization ,Infectious Diseases ,early predictor ,Virology ,Outpatients ,Humans ,Female ,Prospective Studies ,Aged - Abstract
Data regarding early predictors of clinical deterioration in patients with infection of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) is still scarce. The aim of the study is to identify early symptoms or signs that may be associated with severe coronavirus disease 2019(COVID-19).We conducted a multicentre prospective cohort study on a cohort of patients with COVID-19 in home isolation from March 2020 to April 2021. We assessed longitudinal clinical data (fever, dyspnea, need for hospitalization) through video calls at three specific time points: the beginning of symptoms or the day of the first positivity of the nasopharyngeal swab for SARS-CoV-2-RNA (t0 ), and 3 (t3 ) and 7 (t7 ) days after the onset of symptoms. We included 329 patients with COVID-19: 182 (55.3%) males, mean age 53.4 ± 17.4 years, median Charlson comorbidity index(CCI) of 1 (0-3). Of the 329 patients enrolled, 171 (51.98%) had a mild, 81 (24.6%) a moderate, and 77 (23.4%) a severe illness; 151 (45.9%) were hospitalized. Compared to patients with mild COVID-19, moderate and severe patients were older (p
- Published
- 2022
- Full Text
- View/download PDF