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Start Over Author "Fasolini, Marina" Journal journal of medicinal chemistry
8 results on '"Fasolini, Marina"'

1. Correction to Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor

Author

Menichincheri, Maria, primary, Ardini, Elena, additional, Magnaghi, Paola, additional, Avanzi, Nilla, additional, Banfi, Patrizia, additional, Bossi, Roberto, additional, Buffa, Laura, additional, Canevari, Giulia, additional, Ceriani, Lucio, additional, Colombo, Maristella, additional, Corti, Luca, additional, Donati, Daniele, additional, Fasolini, Marina, additional, Felder, Eduard, additional, Fiorelli, Claudio, additional, Fiorentini, Francesco, additional, Galvani, Arturo, additional, Isacchi, Antonella, additional, Borgia, Andrea Lombardi, additional, Marchionni, Chiara, additional, Nesi, Marcella, additional, Orrenius, Christian, additional, Panzeri, Achille, additional, Pesenti, Enrico, additional, Rusconi, Luisa, additional, Saccardo, Maria Beatrice, additional, Vanotti, Ermes, additional, Perrone, Ettore, additional, and Orsini, Paolo, additional

Published
2019
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2. Correction to Discovery of Entrectinib: A New 3-Aminoindazole as a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor

Author

Menichincheri, Maria, Ardini, Elena, Magnaghi, Paola, Avanzi, Nilla, Banfi, Patrizia, Bossi, Roberto, Buffa, Laura, Canevari, Giulia, Ceriani, Lucio, Colombo, Maristella, Corti, Luca, Donati, Daniele, Fasolini, Marina, Felder, Eduard, Fiorelli, Claudio, Fiorentini, Francesco, Galvani, Arturo, Isacchi, Antonella, Borgia, Andrea Lombardi, Marchionni, Chiara, Nesi, Marcella, Orrenius, Christian, Panzeri, Achille, Pesenti, Enrico, Rusconi, Luisa, Saccardo, Maria Beatrice, Vanotti, Ermes, Perrone, Ettore, and Orsini, Paolo

Published
2024
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3. Discovery of Entrectinib: A New 3-Aminoindazole As a Potent Anaplastic Lymphoma Kinase (ALK), c-ros Oncogene 1 Kinase (ROS1), and Pan-Tropomyosin Receptor Kinases (Pan-TRKs) inhibitor

Author

Menichincheri, Maria, primary, Ardini, Elena, additional, Magnaghi, Paola, additional, Avanzi, Nilla, additional, Banfi, Patrizia, additional, Bossi, Roberto, additional, Buffa, Laura, additional, Canevari, Giulia, additional, Ceriani, Lucio, additional, Colombo, Maristella, additional, Corti, Luca, additional, Donati, Daniele, additional, Fasolini, Marina, additional, Felder, Eduard, additional, Fiorelli, Claudio, additional, Fiorentini, Francesco, additional, Galvani, Arturo, additional, Isacchi, Antonella, additional, Borgia, Andrea Lombardi, additional, Marchionni, Chiara, additional, Nesi, Marcella, additional, Orrenius, Christian, additional, Panzeri, Achille, additional, Pesenti, Enrico, additional, Rusconi, Luisa, additional, Saccardo, Maria Beatrice, additional, Vanotti, Ermes, additional, Perrone, Ettore, additional, and Orsini, Paolo, additional

Published
2016
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4. Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

Author

Papeo, Gianluca, primary, Posteri, Helena, additional, Borghi, Daniela, additional, Busel, Alina A., additional, Caprera, Francesco, additional, Casale, Elena, additional, Ciomei, Marina, additional, Cirla, Alessandra, additional, Corti, Emiliana, additional, D’Anello, Matteo, additional, Fasolini, Marina, additional, Forte, Barbara, additional, Galvani, Arturo, additional, Isacchi, Antonella, additional, Khvat, Alexander, additional, Krasavin, Mikhail Y., additional, Lupi, Rosita, additional, Orsini, Paolo, additional, Perego, Rita, additional, Pesenti, Enrico, additional, Pezzetta, Daniele, additional, Rainoldi, Sonia, additional, Riccardi-Sirtori, Federico, additional, Scolaro, Alessandra, additional, Sola, Francesco, additional, Zuccotto, Fabio, additional, Felder, Eduard R., additional, Donati, Daniele, additional, and Montagnoli, Alessia, additional

Published
2015
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5. First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery

Author

Menichincheri, Maria, primary, Bargiotti, Alberto, additional, Berthelsen, Jens, additional, Bertrand, Jay A., additional, Bossi, Roberto, additional, Ciavolella, Antonella, additional, Cirla, Alessandra, additional, Cristiani, Cinzia, additional, Croci, Valter, additional, D’Alessio, Roberto, additional, Fasolini, Marina, additional, Fiorentini, Francesco, additional, Forte, Barbara, additional, Isacchi, Antonella, additional, Martina, Katia, additional, Molinari, Antonio, additional, Montagnoli, Alessia, additional, Orsini, Paolo, additional, Orzi, Fabrizio, additional, Pesenti, Enrico, additional, Pezzetta, Daniele, additional, Pillan, Antonio, additional, Poggesi, Italo, additional, Roletto, Fulvia, additional, Scolaro, Alessandra, additional, Tatò, Marco, additional, Tibolla, Marcellino, additional, Valsasina, Barbara, additional, Varasi, Mario, additional, Volpi, Daniele, additional, Santocanale, Corrado, additional, and Vanotti, Ermes, additional

Published
2009
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6. First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery

Author

Menichincheri, Maria, primary, Bargiotti, Alberto, additional, Berthelsen, Jens, additional, Bertrand, Jay A., additional, Bossi, Roberto, additional, Ciavolella, Antonella, additional, Cirla, Alessandra, additional, Cristiani, Cinzia, additional, Croci, Valter, additional, D’Alessio, Roberto, additional, Fasolini, Marina, additional, Fiorentini, Francesco, additional, Forte, Barbara, additional, Isacchi, Antonella, additional, Martina, Katia, additional, Molinari, Antonio, additional, Montagnoli, Alessia, additional, Orsini, Paolo, additional, Orzi, Fabrizio, additional, Pesenti, Enrico, additional, Pezzetta, Daniele, additional, Pillan, Antonio, additional, Poggesi, Italo, additional, Roletto, Fulvia, additional, Scolaro, Alessandra, additional, Tatò, Marco, additional, Tibolla, Marcellino, additional, Valsasina, Barbara, additional, Varasi, Mario, additional, Volpi, Daniele, additional, Santocanale, Corrado, additional, and Vanotti, Ermes, additional

Published
2008
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8. NMR-Based screening with competition water-ligand observed via gradient spectroscopy experiments: detection of high-affinity ligands.

Author

Dalvit C, Fasolini M, Flocco M, Knapp S, Pevarello P, and Veronesi M

Subjects
Algorithms, Binding, Competitive, Fungi chemistry, Humans, Magnetic Resonance Spectroscopy, Plant Extracts chemistry, Protein Binding, Serum Albumin chemistry, Tryptophan analogs & derivatives, Tryptophan chemistry, Drug Evaluation, Preclinical methods, Ligands, Proteins chemistry, Water chemistry
Abstract

Water-ligand observed via gradient spectroscopy (WaterLOGSY) represents a powerful method for primary NMR screening in the identification of compounds interacting with macromolecules, including proteins and DNA or RNA fragments. The method is useful for the detection of compounds binding to a receptor with binding affinity in the micromolar range. The Achille's heel of the method, as with all the techniques that detect the ligand resonances, is its inability to identify strong ligands with slow dissociation rates. We show here that the use of a reference compound with a known K(D) in the micromolar range together with properly designed competition binding experiments (c-WaterLOGSY) permits the detection of strong binders. A derived mathematical expression is used for the selection of the appropriate setup NMR experimental conditions and for an approximate determination of the binding constant. The experiment requires low ligand concentration, therefore allowing its application in the identification of potential strong inhibitors that are only marginally soluble. The technique is particularly suitable for rapid screening of chemical mixtures and plant or fungi extracts.

Published
2002
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