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Start Over Author "Goodwin NC" Journal journal of medicinal chemistry
5 results on '"Goodwin NC"'

1. Empowering Voices: Inspiring Women in Medicinal Chemistry.

Author

Blanco MJ, Bronson JJ, DiMauro EF, Dzierba C, Eggen M, Garner AL, Georg G, Giarolla J, Goodwin NC, Grenier-Davies MC, Haskell-Luevano C, Holzgrabe U, Huang R, Lagiakos HR, Leftheris K, Martin Y, Matos MJ, May-Dracka TL, Müller CE, Newman AH, Parmee E, Petter JC, Tamayo NA, Wexler RR, Bolognesi ML, Ripka A, and Young W

Subjects
Humans, Female, Chemistry, Pharmaceutical, Power, Psychological
Abstract

As we celebrate International Women's Day 2024 with the theme "Inspire Inclusion", the women of the ACS Medicinal Chemistry Division (MEDI) want to foster a sense of belonging, relevance, and empowerment by sharing uplifting stories of what inspired them to become medicinal chemists. In this editorial, we are featuring female medicinal chemistry scientists to provide role models, encouragement, and inspiration to others. We asked women medicinal chemists to contribute a brief paragraph about what inspired them to become medicinal chemists or what inspires them today as medicinal chemists. The responses and contributions highlight their passions and motivations, such as their love of the sciences and their drive to improve human health by contributing to basic research and creating lifesaving drugs.

Published
2024
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2. Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).

Author

Aldrich J, Allen S, Araujo E, Bronson J, Bryant-Friedrich A, Cyr SK, DiMauro EF, Dzierba C, Garner AL, Georg GI, Goodwin NC, Haranahalli K, Huang R, Leftheris K, May-Dracka TL, Olson ME, and Blanco MJ

Subjects
Humans, Female, United States, Chemistry, Pharmaceutical
Abstract

On the occasion of the 2023 International Women's Day on March 8, 2023, we want to celebrate and highlight the contributions of many women volunteers in the American Chemical Society Division of Medicinal Chemistry (ACS MEDI).

Published
2023
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3. Persistence Pays Off: Milvexian Emerges from the Industry's Longstanding Search for Orally Bioavailable Factor XIa Inhibitors.

Author

Goodwin NC

Subjects
Administration, Oral, Animals, Drug Discovery, Fibrinolytic Agents administration & dosage, Fibrinolytic Agents chemistry, Humans, Molecular Structure, Pyrimidines administration & dosage, Pyrimidines chemistry, Triazoles administration & dosage, Triazoles chemistry, Factor XIa antagonists & inhibitors, Fibrinolytic Agents therapeutic use, Pyrimidines therapeutic use, Triazoles therapeutic use
Abstract

Over the past two decades, Factor XIa inhibitors have emerged as an exciting new class of antithrombic agents. Identification of orally bioavailable small molecule inhibitors has presented a formidable challenge for medicinal chemists. Herein, those challenges and the problem-solving that resulted in the discovery of milvexian will be presented.

Published
2022
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4. Discovery of LX2761, a Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Inhibitor Restricted to the Intestinal Lumen, for the Treatment of Diabetes.

Author

Goodwin NC, Ding ZM, Harrison BA, Strobel ED, Harris AL, Smith M, Thompson AY, Xiong W, Mseeh F, Bruce DJ, Diaz D, Gopinathan S, Li L, O'Neill E, Thiel M, Wilson AG, Carson KG, Powell DR, and Rawlins DB

Subjects
Animals, Benzhydryl Compounds administration & dosage, Benzhydryl Compounds chemical synthesis, Benzhydryl Compounds chemistry, Glucose metabolism, Glucose Tolerance Test, Humans, Hypoglycemic Agents administration & dosage, Hypoglycemic Agents chemical synthesis, Hypoglycemic Agents chemistry, Intestinal Absorption drug effects, Male, Mice, Knockout, Phenylbutyrates administration & dosage, Phenylbutyrates chemical synthesis, Phenylbutyrates chemistry, Structure-Activity Relationship, Thioglycosides administration & dosage, Thioglycosides chemical synthesis, Thioglycosides chemistry, Benzhydryl Compounds pharmacology, Hypoglycemic Agents pharmacology, Phenylbutyrates pharmacology, Sodium-Glucose Transporter 1 antagonists & inhibitors, Thioglycosides pharmacology
Abstract

The increasing number of people afflicted with diabetes throughout the world is a major health issue. Inhibitors of the sodium-dependent glucose cotransporters (SGLT) have appeared as viable therapeutics to control blood glucose levels in diabetic patents. Herein we report the discovery of LX2761, a locally acting SGLT1 inhibitor that is highly potent in vitro and delays intestinal glucose absorption in vivo to improve glycemic control.

Published
2017
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5. Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

Author

Goodwin NC, Mabon R, Harrison BA, Shadoan MK, Almstead ZY, Xie Y, Healy J, Buhring LM, DaCosta CM, Bardenhagen J, Mseeh F, Liu Q, Nouraldeen A, Wilson AG, Kimball SD, Powell DR, and Rawlins DB

Subjects
Animals, Diabetes Mellitus, Type 2 metabolism, Diabetes Mellitus, Type 2 urine, Drug Discovery, Glucose metabolism, Humans, Mice, Substrate Specificity, Xylose administration & dosage, Xylose therapeutic use, Diabetes Mellitus, Type 2 drug therapy, Sodium-Glucose Transporter 2 Inhibitors, Xylose analogs & derivatives, Xylose pharmacology
Abstract

The prevalence of diabetes throughout the world continues to increase and has become a major health issue. Recently there have been several reports of inhibitors directed toward the sodium-dependent glucose cotransporter 2 (SGLT2) as a method of maintaining glucose homeostasis in diabetic patients. Herein we report the discovery of the novel O-xyloside 7c that inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.

Published
2009
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