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Your search keyword '"LaBarbera, Daniel V."' showing total 8 results
Start Over Author "LaBarbera, Daniel V." Journal journal of medicinal chemistry
8 results on '"LaBarbera, Daniel V."'

1. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L

Author

Prigaro, Brett J., primary, Esquer, Hector, additional, Zhou, Qiong, additional, Pike, Laura A., additional, Awolade, Paul, additional, Lai, Xin-He, additional, Abraham, Adedoyin D., additional, Abbott, Joshua M., additional, Matter, Brock, additional, Kompella, Uday B., additional, Messersmith, Wells A., additional, Gustafson, Daniel L., additional, and LaBarbera, Daniel V., additional

Published
2022
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2. Drug Design Targeting T-Cell Factor-Driven Epithelial–Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer

Author

Abraham, Adedoyin D., primary, Esquer, Hector, additional, Zhou, Qiong, additional, Tomlinson, Nicholas, additional, Hamill, Brayden D., additional, Abbott, Joshua M., additional, Li, Linfeng, additional, Pike, Laura A., additional, Rinaldetti, Sébastien, additional, Ramirez, Dominique A., additional, Lunghofer, Paul J., additional, Gomez, Jose D., additional, Schaack, Jerome, additional, Nemkov, Travis, additional, D’Alessandro, Angelo, additional, Hansen, Kirk C., additional, Gustafson, Daniel L., additional, Messersmith, Wells A., additional, and LaBarbera, Daniel V., additional

Published
2019
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3. Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

Author

Medellin, Derek C., primary, Zhou, Qiong, additional, Scott, Robert, additional, Hill, R. Matthew, additional, Frail, Sarah K., additional, Dasari, Ramesh, additional, Ontiveros, Steven J., additional, Pelly, Stephen C., additional, van Otterlo, Willem A. L., additional, Betancourt, Tania, additional, Shuster, Charles B., additional, Hamel, Ernest, additional, Bai, Ruoli, additional, LaBarbera, Daniel V., additional, Rogelj, Snezna, additional, Frolova, Liliya V., additional, and Kornienko, Alexander, additional

Published
2015
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5. Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.

Author

Medellin, Derek C., Qiong Zhou, Scott, Robert, Hill, R. Matthew, Frail, Sarah K., Dasari, Ramesh, Ontiveros, Steven J., Pelly, Stephen C., van Otterlo, Willem A. L., Betancourt, Tania, Shuster, Charles B., Hamel, Ernest, Bai, Ruoli, LaBarbera, Daniel V., Rogelj, Snezna, Frolova, Liliya V., and Kornienko, Alexander

Published
2016
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8. Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase.

Author

Li L, Chang KC, Zhou Y, Shieh B, Ponder J, Abraham AD, Ali H, Snow A, Petrash JM, and LaBarbera DV

Subjects
Amides chemistry, Amides pharmacology, Drug Design, Drug Stability, Enzyme Inhibitors chemistry, Enzyme Inhibitors pharmacology, Glycosides chemistry, Glycosides pharmacology, Humans, Hydrolyzable Tannins chemical synthesis, Aldehyde Reductase antagonists & inhibitors, Amides chemical synthesis, Enzyme Inhibitors chemical synthesis, Glycosides chemical synthesis, Hydrolyzable Tannins chemistry
Abstract

β-Glucogallin (BGG), a major component of the Emblica officinalis medicinal plant, is a potent and selective inhibitor of aldose reductase (AKR1B1). New linkages (ether/triazole/amide) were introduced via high yielding, efficient syntheses to replace the labile ester, and an original two-step (90%) preparation of BGG was developed. Inhibition of AKR1B1was assessed in vitro and using transgenic lens organ cultures, which identified the amide linked glucoside (BGA) as a stable, potent, and selective therapeutic lead toward the treatment of diabetic eye disease.

Published
2014
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