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Your search keyword '"Melissa M. Kemp"' showing total 2 results
Start Over Author "Melissa M. Kemp" Journal journal of medicinal chemistry
2 results on '"Melissa M. Kemp"'

1. Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low-Molecular-Weight Heparin Preparation

Author

Boyangzi Li, Robert J. Linhardt, Melissa M. Kemp, Tyler H. Daman, Michel Weïwer, and Zhenqing Zhang

Subjects
Magnetic Resonance Spectroscopy, Polymers, Clinical events, Extramural, medicine.drug_class, Depolymerization, Chondroitin Sulfates, Anticoagulant, Anticoagulants, Low molecular weight heparin, Heparin, Heparin, Low-Molecular-Weight, Article, Glycosaminoglycan, chemistry.chemical_compound, chemistry, Biochemistry, Drug Discovery, medicine, Molecular Medicine, Chondroitin sulfate, medicine.drug
Abstract

Heparin, a widely used anticoagulant, is being rapidly displaced by low-molecular-weight heparins. Recently, certain lots of heparin have been associated with anaphylactoid-type reactions resulting from contamination with oversulfated chondroitin sulfate. This impurity has also contaminated low-molecular-weight heparins obtained by chemical and enzymatic depolymerization of heparin. The sensitivity of oversulfated chondroitin sulfate to five different depolymerization processes similar to ones used in preparing low-molecular-weight heparins is reported.

Published
2008
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