1. Identification of
- Author
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Ryan, Moslin, Yanlei, Zhang, Stephen T, Wrobleski, Shuqun, Lin, Michael, Mertzman, Steven, Spergel, John S, Tokarski, Joann, Strnad, Kathleen, Gillooly, Kim W, McIntyre, Adriana, Zupa-Fernandez, Lihong, Cheng, Huadong, Sun, Charu, Chaudhry, Christine, Huang, Celia, D'Arienzo, Elizabeth, Heimrich, Xiaoxia, Yang, Jodi K, Muckelbauer, ChiehYing, Chang, Jeffrey, Tredup, Dawn, Mulligan, Dianlin, Xie, Nelly, Aranibar, Manoj, Chiney, James R, Burke, Louis, Lombardo, Percy H, Carter, and David S, Weinstein
- Subjects
Niacinamide ,TYK2 Kinase ,Mice ,Structure-Activity Relationship ,Allosteric Regulation ,Nicotinic Acids ,Animals ,Humans ,Ligands ,Protein Kinase Inhibitors - Abstract
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide
- Published
- 2019