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Your search keyword '"Tsou, Lun K."' showing total 7 results
Start Over Author "Tsou, Lun K." Journal journal of medicinal chemistry
7 results on '"Tsou, Lun K."'

1. Linker Optimization and Therapeutic Evaluation of Phosphatidylserine-Targeting Zinc Dipicolylamine-based Drug Conjugates

Author

Liu, Yu-Wei, primary, Chen, Yun-Yu, additional, Hsu, Chia-Yu, additional, Chiu, Tai-Yu, additional, Liu, Kuan-Liang, additional, Lo, Chen-Fu, additional, Fang, Ming-Yu, additional, Huang, Yu-Cheng, additional, Yeh, Teng-Kuang, additional, Pak, Koon Y., additional, Gray, Brian D., additional, Hsu, Tsu-An, additional, Huang, Kuan-Hsun, additional, Shih, Chuan, additional, Shia, Kak-Shan, additional, Chen, Chiung-Tong, additional, and Tsou, Lun K., additional

Published
2019
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2. Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond

Author

Wu, Chien-Huang, primary, Song, Jen-Shin, additional, Kuan, Hsuan-Hao, additional, Wu, Szu-Huei, additional, Chou, Ming-Chen, additional, Jan, Jiing-Jyh, additional, Tsou, Lun K., additional, Ke, Yi-Yu, additional, Chen, Chiung-Tong, additional, Yeh, Kai-Chia, additional, Wang, Sing-Yi, additional, Yeh, Teng-Kuang, additional, Tseng, Chen-Tso, additional, Huang, Chen-Lung, additional, Wu, Mine-Hsine, additional, Kuo, Po-Chu, additional, Lee, Chia-Jui, additional, and Shia, Kak-Shan, additional

Published
2018
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3. Development of Stem-Cell-Mobilizing Agents Targeting CXCR4 Receptor for Peripheral Blood Stem Cell Transplantation and Beyond

Author

Wu, Chien-Huang, Song, Jen-Shin, Kuan, Hsuan-Hao, Wu, Szu-Huei, Chou, Ming-Chen, Jan, Jiing-Jyh, Tsou, Lun K., Ke, Yi-Yu, Chen, Chiung-Tong, Yeh, Kai-Chia, Wang, Sing-Yi, Yeh, Teng-Kuang, Tseng, Chen-Tso, Huang, Chen-Lung, Wu, Mine-Hsine, Kuo, Po-Chu, Lee, Chia-Jui, and Shia, Kak-Shan

Abstract

The function of the CXCR4/CXCL12 axis accounts for many disease indications, including tissue/nerve regeneration, cancer metastasis, and inflammation. Blocking CXCR4 signaling with its antagonists may lead to moving out CXCR4+cell types from bone marrow to peripheral circulation. We have discovered a novel series of pyrimidine-based CXCR4 antagonists, a representative (i.e., 16) of which was tolerated at a higher dose and showed better HSC-mobilizing ability at the maximal response dose relative to the approved drug 1(AMD3100), and thus considered a potential drug candidate for PBSCT indication. Docking compound 16into the X-ray crystal structure of CXCR4 receptor revealed that it adopted a spider-like conformation striding over both major and minor subpockets. This putative binding mode provides a new insight into CXCR4 receptor–ligand interactions for further structural modifications.

Published
2024
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4. Stem Cell Mobilizers Targeting Chemokine Receptor CXCR4: Renoprotective Application in Acute Kidney Injury

Author

Wu, Chien-Huang, primary, Song, Jen-Shin, additional, Chang, Kuei-Hua, additional, Jan, Jiing-Jyh, additional, Chen, Chiung-Tong, additional, Chou, Ming-Chen, additional, Yeh, Kai-Chia, additional, Wong, Ying-Chieh, additional, Tseng, Chen-Tso, additional, Wu, Szu-Huei, additional, Yeh, Ching-Fang, additional, Huang, Chung-Yu, additional, Wang, Min-Hsien, additional, Sadani, Amit A., additional, Chang, Chun-Ping, additional, Cheng, Chia-Yi, additional, Tsou, Lun K., additional, and Shia, Kak-Shan, additional

Published
2015
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5. Function-Oriented Development of CXCR4 Antagonists as Selective Human Immunodeficiency Virus (HIV)-1 Entry Inhibitors

Author

Wu, Chien-Huang, primary, Wang, Chuan-Jen, additional, Chang, Chun-Ping, additional, Cheng, Yung-Chi, additional, Song, Jen-Shin, additional, Jan, Jiing-Jyh, additional, Chou, Ming-Chen, additional, Ke, Yi-Yu, additional, Ma, Jing, additional, Wong, Ying-Chieh, additional, Hsieh, Tsung-Chih, additional, Tien, Yun-Chen, additional, Gullen, Elizabeth A., additional, Lo, Chen-Fu, additional, Cheng, Chia-Yi, additional, Liu, Yu-Wei, additional, Sadani, Amit A., additional, Tsai, Chia-Hua, additional, Hsieh, Hsin-Pang, additional, Tsou, Lun K., additional, and Shia, Kak-Shan, additional

Published
2015
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