1. Nucleotide sequence of the Escherichia coli K12 histidine operon revisited.
- Author
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Jovanović G, Kostić T, Janković M, and Savić DJ
- Subjects
- Base Sequence, Mutation genetics, Salmonella typhimurium genetics, Sequence Analysis, DNA, Escherichia coli genetics, Genes, Bacterial genetics, Histidine genetics, Operon genetics
- Abstract
We report on a significant difference between the published nucleotide sequence of the Escherichia coli K12 histidine operon and our sequencing results repeatedly obtained from a number of different E. coli K12 strains. The discrepancies include 39 base-pair changes and one addition located predominantly in the proximal portion of the operon. Our data also suggest that neutral and near-neutral mutations do not accumulate to a significant extent in the histidine operon of E. coli strains harbouring strong mutator alleles.
- Published
- 1994
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