1. Kinetic investigation of cross-coupling reaction steps by advanced competing reaction methods
- Author
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Alexander F. Schmidt, E. V. Yarosh, A. A. Kurokhtina, and E. V. Larina
- Subjects
Reaction mechanism ,010405 organic chemistry ,Chemistry ,Process Chemistry and Technology ,Sonogashira coupling ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,Coupling reaction ,0104 chemical sciences ,Catalytic cycle ,Heck reaction ,Elementary reaction ,Stepwise reaction ,Physical and Theoretical Chemistry ,Reaction progress kinetic analysis - Abstract
Investigating the mechanism of a complex catalytic reaction is usually quite complicated because many processes, such as active catalyst formation and deactivation, are linked to the main catalytic cycle. Using artificial multi-route reactions with similar competing substrates is a unique way to elucidate the fine details of a reaction mechanism. Applying such multi-route reaction-based methods to the cross-coupling of alkynes with aryl halides (Cu-free Sonogashira reaction) and alkenes with aromatic carboxylic anhydrides (modified Heck reaction) catalysed by ligand-free Pd allowed us to elucidate the fast, reversible, and rate-determining steps involved in the relevant catalytic cycles.
- Published
- 2016
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