1. Insights into the interaction between lipid bilayers and trehalose aqueous solutions.
- Author
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Kumar, Amit, Cincotti, Alberto, and Aparicio, Santiago
- Subjects
- *
BILAYER lipid membranes , *AQUEOUS solutions , *TREHALOSE , *INTERMOLECULAR forces , *MOLECULAR dynamics , *CHEMICAL bonds , *MEMBRANE lipids - Abstract
The properties of lipid bilayers in contact with trehalose solutions in water were studied in the full concentration range using molecular dynamics simulations. The mechanism of trehalose interaction with the bilayer surface was analysed considering hydrogen bonding and molecular arrangements as well as the possible changes in bilayer properties. The effect of concentration of the possible mechanisms of trehalose action as membrane protectant were discussed to infer the possible evolution of water replacement by trehalose at the membrane surface and its relationship with the trehalose role in anhydrobiosis and drying processes. Unlabelled Image • Anhidrobiosis in presence of trehalose • Trehalose solution in presence interacting with lipid membranes • Water replacement mechanisms • Intermolecular forces at lipid bilayer interfaces • Nanoscopic characterization of bilayer structuring upon water replacement [ABSTRACT FROM AUTHOR]
- Published
- 2020
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