In this paper, a chirality-sensitive effective orientational potential is, for the first time, proposed. It describes, within the Molecular Field approximation, different solute-solvent ordering interactions, according to the P (clockwise) or M (counterclockwise) nature of helical particles dissolved in uniaxial anisotropic solvents composed, in their turn, of helical P or M particles. By making use of Monte Carlo-simulated order parameters, it is shown that the model is, in principle, able to lead to the absolute enantiorecognition of the unknown chirality of the helical solute particles. This makes it a possible interesting tool for exploiting NMR anisotropic observables in order to achieve the absolute enantiomer assignment of chiral helical solutes. Unlabelled Image • Helical solutes orientationally ordered in organized helical solvents are studied. • A mean torque potential sensitive to P (clockwise) and M (counterclockwise) chirality is formulated. • The effectiveness and reliability of the proposed model is tested on Monte Carlo simulated order parameters. • The model proved to be, in principle, a useful tool for absolute enantiorecognition of the solutes. [ABSTRACT FROM AUTHOR]