1. 3+2-Dipolar cycloaddition of dianhydrohexitol azidoderivatives with N-arylmaleimides
- Author
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T. G. Drushlyak, Svetlana V. Shishkina, Nikolay L. Babak, Victoria V. Lipson, Vladimir I. Musatov, and I. M. Gella
- Subjects
Chemistry ,Stereochemistry ,Organic Chemistry ,Griseolic acid ,Cycloaddition ,Analytical Chemistry ,Dianhydrohexitol ,Inorganic Chemistry ,Dipole ,chemistry.chemical_compound ,Pharmaceutics ,Two-dimensional nuclear magnetic resonance spectroscopy ,Spectroscopy ,Heteronuclear single quantum coherence spectroscopy - Abstract
Dianhydrohexitol azides dipolar 3+2 cycloaddition with N-arylmaleimides has been studied with NMR (1H and 13C, COSY, NOESY and HSQC) and X-ray analysis. In spite of low asymmetrical induction in this reaction, diastereomerically pure products have been obtained. These products are interesting over their structural similarity to griseolic acid derivatives and dihydropyrrolotriazoles, significant for pharmaceutics.
- Published
- 2015
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