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In this study, graft polymerization of glycidyl methacrylate (GMA) monomer onto crosslinked poly (vinyl alcohol), CPVA was carried and then it was aimed to be functionalized by modifying with amine groups. The characterization of the obtained samples was carried out by Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). It was found that the equilibrium degree of swelling (SDD) of the functionalized sample has changed at different pH's, the highest SSD value was obtained at pH 2.1. Trypan blue (TB) as a anionic drug and 5-flurasil (5-FU) as a non-ionic drug were chosen as model drugs to perform the drug loading and release studies. As a result, it has been observed that the obtained samples and drugs have different charge groups so the amounts of loaded drugs and therefore the amounts of the releases differ. [ABSTRACT FROM AUTHOR]