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Your search keyword '"Mitsuko Yamada"' showing total 3 results
Start Over Author "Mitsuko Yamada" Journal journal of natural medicines
3 results on '"Mitsuko Yamada"'

1. Analysis of CYP3A inhibitory components of star fruit (Averrhoa carambola L.) using liquid chromatography–mass spectrometry

Author

Manabu Okumura, Akiyo Sakushima, Mitsuko Yamada, Muneaki Hidaka, Eri Shimizu, Kazuhiko Arimori, and Shinzo Hosoi

Subjects
CYP3A, Trimer, In Vitro Techniques, Mass spectrometry, Inhibitory postsynaptic potential, Catechin, Mass Spectrometry, Averrhoa carambola, Magnoliopsida, chemistry.chemical_compound, Liquid chromatography–mass spectrometry, Biflavonoids, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Humans, Proanthocyanidins, Procyanidin B1, Chromatography, biology, Plant Extracts, Chemistry, Stereoisomerism, biology.organism_classification, Fruit, Microsomes, Liver, Molecular Medicine, Chromatography, Liquid
Abstract

In this study, we analyzed the CYP3A inhibitory components of star fruit Averrhoa carambola L., using liquid chromatography-mass spectrometry (LC-MS). The stereoisomer of procyanidin B1 and B2 and/or the trimer consisting of catechin and/or epicatechin were suggested to be potent inhibitory components.

Published
2008
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2. Isolation of cytochrome P450 3A (CYP3A) inhibitors from Hyuganatsu, Citrus tamurana Hort

Author

Manabu Okumura, Mitsuko Yamada, Eri Shimizu, Akiyo Sakushima, Noriyuki Usami, Shinzo Hosoi, Ikuo Yamamoto, Muneaki Hidaka, and Kazuhiko Arimori

Subjects
Cytochrome P450 3A, Human liver, Limonin, CYP3A, Biology, Limonoid, Citrus tamurana, chemistry.chemical_compound, chemistry, Biochemistry, Enzyme inhibitor, medicine, biology.protein, Microsome, Molecular Medicine, medicine.drug
Abstract

The present study was conducted to identify cytochrome P450 3A (CYP3A) inhibitory components of Hyuganatsu, Citrus tamurana Hort., by investigating the effects on midazolam 1'-hydroxylase activity of human liver microsomes. As a consequence, limonin and nomilin were identified as CYP3A inhibitors from the endocarp of Hyuganatsu.

Published
2006
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3. Main phenolic compounds from the flower of Trachelospermum asiaticum var. intermedium (Apocynaceae)

Author

Akiyo Sakushima, Eiji Sakai, Mitsuko Yamada, Eri Shimizu, Shinzo Hosoi, and Toshihiro Tanaka

Subjects
Magnetic Resonance Spectroscopy, Apocynaceae, biology, Plant Extracts, Trachelospermum asiaticum, Pharmacology toxicology, Flowers, biology.organism_classification, Quercitrin, chemistry.chemical_compound, chemistry, Phenols, Tracheloside, Botany, Molecular Medicine, Spectral data
Abstract

Six phenolic compounds were isolated from the flowers of Trachelospermum asiaticum var. intermedium (Apocynaceae). These structures were determined on the basis of spectral data.

Published
2007

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