1. Two new oleanane derivatives from the fruits of Leonurus japonicus and their cytotoxic activities
- Author
-
Dayong Peng, Zhong-Hua Xiong, Wenwen Peng, Li-Xia Zheng, Guanghu Huo, and Xugen Shi
- Subjects
Molecular Structure ,biology ,Cytotoxins ,010405 organic chemistry ,Stereochemistry ,Leonurus japonicus ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,HeLa ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Leonurus ,chemistry ,Fruit ,Ic50 values ,Humans ,Molecular Medicine ,Cytotoxic T cell ,Oleanane Triterpenes ,Oleanolic Acid ,Cancer cell lines ,Cytotoxicity ,Oleanane - Abstract
Two new oleanane derivatives, leonuronins A and B (1 and 2), along with three known oleanane triterpenes (3–5) were isolated from the fruits of Leonurus japonicus. Their structures were elucidated on the basis of NMR, MS, IR and UV spectroscopic data. The new compounds were tested for cytotoxic activities against A549 and Hela cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxicity with IC50 values ranging from 6.97 to 18.13 μM.
- Published
- 2018