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Your search keyword '"Fakhr, I"' showing total 2 results
Start Over Author "Fakhr, I" Journal journal of natural products
2 results on '"Fakhr, I"'

1. Chemical Studies of Egyptian Opisthobranchs:  Spongian Diterpenoids from Glossodoris atromarginata

Author

Fontana, A., Mollo, E., Ricciardi, D., Fakhr, I., and Cimino, G.

Abstract

Five new spongian diterpenoids 1−5 have been isolated from the mollusk Glossodoris atromarginata along with four known related metabolites (6−9). The structures were solved by extensive spectroscopic analysis and chemical correlation. The absolute stereochemistry of compound 2 was determined by Mosher's method. A dietary origin is inferred for all these molecules on the basis of their structural analogies with known sponge metabolites, but their transfer from the digestive glands to the dorsal skin suggests a defensive role to thwart predation.

Published
1997

2. In vitro pharmacological and toxicological effects of norterpene peroxides isolated from the Red Sea sponge Diacarnus erythraeanus on normal and cancer cells.

Author

Lefranc F, Nuzzo G, Hamdy NA, Fakhr I, Moreno Y Banuls L, Van Goietsenoven G, Villani G, Mathieu V, van Soest R, Kiss R, and Ciavatta ML

Subjects
Animals, Antineoplastic Agents chemistry, Apoptosis drug effects, Drug Screening Assays, Antitumor, Humans, Indian Ocean, Inhibitory Concentration 50, Molecular Structure, Peroxides chemistry, Reactive Oxygen Species metabolism, Terpenes chemistry, Antineoplastic Agents isolation & purification, Antineoplastic Agents pharmacology, Peroxides isolation & purification, Peroxides pharmacology, Porifera chemistry, Terpenes isolation & purification, Terpenes pharmacology
Abstract

Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC₅₀ growth inhibitory concentrations in vitro of <10 μM, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells.

Published
2013
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