1. Bunodosine 391: an analgesic acylamino acid from the venom of the sea anemone Bunodosoma cangicum.
- Author
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Zaharenko AJ, Picolo G, Ferreira WA Jr, Murakami T, Kazuma K, Hashimoto M, Cury Y, de Freitas JC, Satake M, and Konno K
- Subjects
- Analgesics chemistry, Animals, Cnidarian Venoms chemical synthesis, Cnidarian Venoms chemistry, Cnidarian Venoms isolation & purification, Cnidarian Venoms pharmacology, Edema chemically induced, Edema drug therapy, Hindlimb drug effects, Male, Molecular Structure, Naloxone pharmacology, Narcotic Antagonists pharmacology, Nuclear Magnetic Resonance, Biomolecular, Rats, Rats, Wistar, Receptors, Serotonin drug effects, Receptors, Serotonin metabolism, Analgesics isolation & purification, Analgesics pharmacology, Sea Anemones chemistry
- Abstract
A new acylamino acid, bunodosine 391 (BDS 391), was isolated from the venom of the sea anemone Bunodosoma cangicum. The structure was elucidated by spectroscopic analyses (2D NMR, ESIMS/MS) and verified by its synthesis. Intraplantar injection of BDS 391 into the hind paw of a rat induced a potent analgesic effect. This effect was not altered by naloxone (an opioid receptor antagonist), but was completely reversed by methysergide (a serotonin receptor antagonist), indicating that the effect is mediated by activation of serotonin receptors.
- Published
- 2011
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