1. Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius
- Author
-
Florent Blanchard, Fanny Roussi, Tiphaine Péresse, Jean-Luc Wolfender, Pierre-Marie Allard, Marc Litaudon, Doan T. M. Huong, Gwenaëlle Jézéquel, Jérôme Bignon, VC Pham, and Hélène Levaique
- Subjects
0301 basic medicine ,Pharmaceutical Science ,Drug Screening Assays ,01 natural sciences ,Analytical Chemistry ,Drug Discovery ,Stilbenes ,Organic chemistry ,Cytotoxic T cell ,Phytogenic/chemistry/isolation & purification/pharmacology ,ddc:615 ,Flavonoids/chemistry ,biology ,Molecular Structure ,Chemistry ,Euphorbiaceae ,Plant Leaves/chemistry ,Phytochemical ,Vietnam ,Molecular networking ,Molecular Medicine ,Cancer cell lines ,Euphorbiaceae/chemistry ,Stereochemistry ,Nuclear Magnetic Resonance ,Antineoplastic Agents ,Macaranga tanarius ,Stilbenes/chemistry/isolation & purification/pharmacology ,03 medical and health sciences ,Prenylation ,medicine ,Humans ,Macaranga ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,Flavonoids ,010405 organic chemistry ,Organic Chemistry ,Antitumor ,biology.organism_classification ,medicine.disease ,Antineoplastic Agents, Phytogenic ,0104 chemical sciences ,Plant Leaves ,030104 developmental biology ,Complementary and alternative medicine ,Fruit/chemistry ,Fruit ,Drug Screening Assays, Antitumor ,Glioblastoma ,Biomolecular - Abstract
With the aim of discovering new cytotoxic prenylated stilbenes of the schweinfurthin series, Macaranga tanarius was selected for detailed phytochemical investigation among 21 Macaranga species examined by using a molecular networking approach. From an ethanol extract of the fruits, seven new prenylated stilbenes, schweinfurthins K–Q (7–13), were isolated, along with vedelianin (1), schwenfurthins E–G (2–4), mappain (5), and methyl-mappain (6). The structures of the new compounds were established by spectroscopic data analysis. The relative configurations of compounds 8, 12, and 13 were determined based on ROESY NMR spectroscopic analysis. The cytotoxic activities of compounds 1–13 were evaluated against the human glioblastoma (U87) and lung (A549) cancer cell lines.
- Published
- 2017