1. Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds
- Author
-
Hirotaka Ishigaki, Yoshiteru Oshima, Haruhisa Kikuchi, Kyoichi Iizumi, Katsunori Takahashi, Ikuko Ito, and Yuzuru Kubohara
- Subjects
Cell Survival ,Pharmaceutical Science ,010402 general chemistry ,01 natural sciences ,Jurkat cells ,Dictyostelium discoideum ,Analytical Chemistry ,Jurkat Cells ,Drug Discovery ,Slime mold ,Concanavalin A ,Hydrocarbons, Chlorinated ,Humans ,Dictyostelium ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,biology ,Molecular Structure ,010405 organic chemistry ,fungi ,Organic Chemistry ,Biological activity ,T lymphocyte ,Resorcinols ,biology.organism_classification ,0104 chemical sciences ,Hexanones ,Complementary and alternative medicine ,Biochemistry ,Cell culture ,Polyketides ,biology.protein ,Molecular Medicine ,Interleukin-2 ,Dictyosteliida ,HeLa Cells - Abstract
Eight chlorinated alkylresorcinols, monochasiol A–H (1–8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1–8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.
- Published
- 2017