1. Indole Alkaloid Glycosides from the Aerial Parts of Strobilanthes cusia
- Author
-
Wei Gu, Fu-Mei Yang, Chunlin Long, Yu Zhang, Kuo Hsiung Lee, Susan L. Morris-Natschke, Qian-Yun Sun, Yue-Hu Wang, and Xiao-Jiang Hao
- Subjects
Staphylococcus aureus ,Stereochemistry ,Pharmaceutical Science ,Microbial Sensitivity Tests ,Indole Alkaloids ,Analytical Chemistry ,chemistry.chemical_compound ,Acanthaceae ,Drug Discovery ,Glycosides ,Nuclear Magnetic Resonance, Biomolecular ,Pharmacology ,chemistry.chemical_classification ,Strobilanthes cusia ,Molecular Structure ,Indole alkaloid ,Organic Chemistry ,Glycoside ,Phenylethanoid ,Anti-Bacterial Agents ,Complementary and alternative medicine ,chemistry ,Molecular Medicine ,Indirubin ,Antibacterial activity ,Drugs, Chinese Herbal - Abstract
Three indole alkaloid glycosides, strobilanthosides A-C (1-3), two known indole alkaloid glucosides (4 and 5), and five phenylethanoid glycosides (8-10) were isolated from the aerial parts of Strobilanthes cusia. The structures of the new compounds were elucidated by spectrometric analysis, and the absolute configurations of 1 and 2 were established by ECD spectrocsopy. N'-β-d-Glucopyranosylindirubin (5) showed weak antibacterial activity (MIC 62.5-125 μM) against Staphylococcus aureus.
- Published
- 2014