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Your search keyword '"Yanpeng Hou"' showing total 2 results
Start Over Author "Yanpeng Hou" Journal journal of natural products
2 results on '"Yanpeng Hou"'

1. Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp

Author

Yanpeng Hou, Tim S. Bugni, Doug R. Braun, E Vazquez-Rivera, and Thomas P. Wyche

Subjects
Methicillin-Resistant Staphylococcus aureus, Pharmaceutical Science, Peptidolipin E, Marine Biology, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Nocardia, Article, Analytical Chemistry, Microbiology, Lipopeptides, Drug Discovery, medicine, Animals, Urochordata, Pharmacology, chemistry.chemical_classification, Molecular Structure, Organic Chemistry, Nocardia sp, biology.organism_classification, bacterial infections and mycoses, Trididemnum, Methicillin-resistant Staphylococcus aureus, Amino acid, Anti-Bacterial Agents, Complementary and alternative medicine, chemistry, Staphylococcus aureus, Molecular Medicine, Antibacterial activity
Abstract

A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1–5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. Advanced Marfey’s method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).

Published
2012

2. Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp. madagascariensis from the Madagascar rainforest

Author

Chris Birkinshaw, Peggy J. Brodie, Fidisoa Ratovoson, David G. I. Kingston, Shugeng Cao, James S. Miller, Roland Rakotondrajaona, Rabodo Andriantsiferana, Vincent E. Rasamison, and Yanpeng Hou

Subjects
Stereochemistry, Pharmaceutical Science, Rainforest, Pharmacognosy, Biology, Article, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, Madagascar, Humans, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, Plants, Medicinal, Molecular Structure, Organic Chemistry, Cordyla madagascariensis, Fabaceae, Carbon-13 NMR, Antineoplastic Agents, Phytogenic, Terpenoid, Complementary and alternative medicine, chemistry, Fruit, Molecular Medicine, Female, Diterpene, Diterpenes, Drug Screening Assays, Antitumor, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of the fruits of Cordyla madagascariensis ssp. madagascariensis led to the isolation of the four new cassane diterpenoids 1-4. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HSQC, HMBC, and ROESY sequences. All of the isolates were tested against the A2780 human ovarian cancer cell line, and compounds 1 and 2 showed mild antiproliferative activity with IC50 values of 10 and 36 microM, respectively.

Published
2008

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