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Thalassemia is a rare, complex disease, representing a group of disorders of hemoglobin synthesis that are characterized by reduced synthesis of either the alpha-globin or β-globin chains of the hemoglobin molecule. Defective synthesis of β-globin resulting from a variety of molecular defects causes β-thalassemia. Thalassemia is an autosomal recessive disorder, which requires prompt diagnosis and an appropriate treatment. Thorough clinical, radiographic and laboratory assessment helps in diagnosing thalassemia and any other hematological disorder. Here, two cases of β-thalassemia showing distinct features are presented and the importance of detailed work-up of the cases has been highlighted. [ABSTRACT FROM AUTHOR]

Objectives: This study was conducted to analyze and identify differences in the palatal rugae patterns and to identify gender wise changes in the palatal rugae shapes in populations of five different states of India. Study Design: Study was conducted in five different Indian states. 500 sample subjects from Andhra Pradesh, Tamil Nadu, Karnataka, Madhya Pradesh and Maharashtra were included. Rugae patterns with predominant shapes were analyzed and categorized according to different states and both genders, data was statistically analyzed using SPSS software 15.0 and the results were obtained by Chi-square analysis. Results: "Wavy" type of palatal rugae pattern is the most predominant variant in five different study groups in both the genders. Conclusion: This study could identify variations in distribution of various palatal rugae pattern in five different states and confirmed the "wavy" type of palatal rugae patterns to be the most predominant variant in five different study groups. [ABSTRACT FROM AUTHOR]