1. Single- and hypofractionated stereotactic radiosurgery for large (> 2 cm) brain metastases: a systematic review
- Author
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Kyu Sun Choi, Eun Suk Park, Eun Jung Lee, and Young Hyun Cho
- Subjects
Cancer Research ,business.industry ,Incidence (epidemiology) ,medicine.medical_treatment ,Cochrane Library ,Effective dose (radiation) ,Radiosurgery ,Radiation necrosis ,Neurology ,Oncology ,Sample size determination ,Toxicity ,Medicine ,In patient ,Neurology (clinical) ,business ,Nuclear medicine - Abstract
Since frameless stereotactic radiosurgery (SRS) techniques have been recently introduced, hypofractionated SRS (HF-SRS) for large brain metastases (BMs) is gradually increasing. To verify the efficacy and safety of HF-SRS for large BMs, we aimed to perform a systematic review and compared them with SF-SRS. We systematically searched the studies regarding SF-SRS or HF-SRS for large (> 2 cm) BM from databases including PubMed, Embase, and the Cochrane Library on July 31, 2018. Biologically effective dose with the α/β ratio of 10 (BED10), 1-year local control (LC), and radiation necrosis (RN) were compared between the two groups, with the studies being weighted by the sample size. The 15 studies with 1049 BMs that described 1-year LC and RN were included. HF-SRS tended to be performed in larger tumors; however, higher mean BED10 (50.1 Gy10 versus 40.4 Gy10, p
- Published
- 2021